Application of Polyphenol (Tannin)-Rich Leaf Extracts of Cotinus coggygria Scop., Cultivated in Georgia, in Endodontic Practice

In order to achieve effective and predictable outcomes in clinical endodontics, the search for novel therapeutic methods and agents remains highly relevant in contemporary dental practice. Considering the etiological factors of endodontic diseases, thorough and effective disinfection of the root canal system represents a fundamental prerequisite for successful treatment.

The present study aims to evaluate the rationale for implementing an extract of Thrimli, a plant cultivated in Georgia, in endodontic practice. The selection of this agent was determined by its high content of polyphenolic compounds, which are known to provide broad-spectrum antimicrobial activity inherent to natural raw materials.

This article reviews the results of all key preclinical in vitro experiments conducted as part of a retrospective framework for the continuation of in vivo and subsequent clinical investigations. Specifically, the study assesses the cytotoxicity, safety, allergenicity, biocompatibility, and local irritative effects of the experimental irrigating solution; evaluates its microbiological activity; determines the optimal extract fraction and solution concentration; and analyzes its compatibility with other commonly used endodontic irrigants.