Keywords
სუპოზიტორიები
კაროტინოიდები
ცხიმოვანი მჟავები
კაროტინოიდების გამოთავისუფლების კინეტიკა
How to Cite
Abstract
Sea-buckthorn (Hippophae rhamnoides L, fam. Eleagnaceae) is one of the most widespread plants of the Georgian flora. Its rich chemical composition determines a variety of pharmacological effects in the treatment of burns, gastritis, gastric and duodenal ulcers, cervical erosion, radiation diseases of the skin and esophagus, and others [1,2,3]. The object of the research were vaginal suppositories made using fruit oil from Georgian sea-buckthorn. Model suppositories with Hippophae rhamnoides oil based on cocoa butter and Vitepsol W35 were developed. These suppositories were standardized with the sum of carotenoids - 0.66-0.75 mg/sup. (converted to β-carotene). Comparison of the in vitro release profile of carotenoids from sea-buckthorn oil 0.3 g vaginal suppositories shows that the samples prepared on both bases are characterized by prolonged release, while the process is more intense with the diphyllous base (Vitepsol W 35), which is recommended as the main suppository base for sea-buckthorn suppositories. The leading fatty acids of this oil are identified in suppositories - palmitic, oleic and stearic acids. The physicochemical and structural-mechanical indicators of suppositories were defined.
References
Машковский М.Д., Лекарственные средства:В 2-х томах.М. Медицина.1996
Справочник лекарственных средств Vidal, https://www.vidal. ru/drugs/ hippophaes_oleum__419692
Халеева Л.Д., Петренко И.Г. ,Влияние суппозиториев с облепиховым маслом на течение экспериментального проктита и кольпита.,2-ая Респ.Конф по мед ботанике.тез.докл.Киев,1988.с.318
Головкин В.А., и др., Приготовление и изучение супозиториев с коргликоном ХФЖ.1997.№12.с.90-93.
Майорова А.В., Кондратьева Т.С., Исследование высвобождения БАВ сухого экстракта арники из суппозиториев в опытах in vitro,Науч.Труды НИИФ.М.,1998.т.37.ч.1.с.170-173.
Тринеева О.В. , Комплексное исследование содержания и специфического профиля БАВ плодов облепихи крушиновидной.Воронеж:Издательский дом ВГУ,2016.224с.
Демина Н.Б, Анурова М.Н., Суппозитории: аспекты модернизации лекарственной формы, Разработка и регистрация лекарственных средств 2016 №4 (17), с.92-97.
Гукасова-Федорова Н.Я., Селезнова Е.Д. , Лечение эрозии шейки матки облепиховым маслом, Акушерство и гинекология, 1995, N5, c.57-58
Petra S Larmo , Baoru Yang , Juha Hyssälä , Heikki Kallio , Risto Erkkola, Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: A randomized, double-blind, placebo-controlled study, Maturitas,Volume 79, Issue 3, November 2014, Pages 316-321, https://doi.org/10.1016/j.maturitas.2014.07.010
Risto Erkkola, Baoru Yang , Sea buckthorn oils: Towards healthy mucous membranes, Women’s Health, http://www.scicompdf.se/membrasin/yang_erk_2003.pdf
Патент РФ 2122851б6А61К9/02;35/78, 1998г.
Патент РФ 2097022, 6А61К 9/02 , 1997г.
Патент РФ 2212882С1А61К9/02,А61К 35/78 А61 Р43/00 , 2003г
სახელმწიფო ფარმაკოპეა, ტომი 2, თბილისი, 2003, გვ.80-82
ბაკურიძე ა., წამლის სამრეწველო ტექნოლოგია, თბილისი, 2006.
ОФС - суппозитории 1.4.1.0013.15 Взамен ст.ГФ x
ФС- 42-1730- 98 Масло облепиховое
Масло облепиховое «Oblepiha22», Технические условия, 2002 https://www.oblepiha22.ru/assets/maslo_oblepihovoye_tu.pdf
Kovàts E., Characterization of organic compounds by gas chromatography. Part 1. Retention indices of aliphatic halides, alcohols, aldehydes and ketones. Helvetica Chimica Acta, 41, 1915-1932, 1958
Salova V.G., Odintsova E.B., Kozlova Zh.M, Comparison of metods for determining the release of itraconazole from vaginal suppositories, "Medical & pharmaceutical journal "Pulse" , 2020. Vol. 22. N 6, http://dx.doi.org/10.26787/nydha-2686-6838-2020-22-6-79-83.
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