Pharmacognostical study of aerial Parts of Thymus collinus Bieb. growing in Georgia


Biological activity
essential oil
Thymus collinus

How to Cite

Korkotadze, T., Berashvili, D., Getia, M., Mchedlidze, K., Legault, J., & Mshvildadze, V. (2024). Pharmacognostical study of aerial Parts of Thymus collinus Bieb. growing in Georgia. Georgian Scientists, 6(1), 87–94.


A study of the chemical composition of the essential oil obtained from the aerial parts of Thymus collinus Bieb., collected in Kvemo Kartli floristic area (Georgia), endemic to caucasus, was carried out. The percentage of terpenic components was determined by gas chromatography. The major components of essential oil are nerolidol (43.42 %) and carvacrol (21.40 %). The oxygenated sesquiterpens are dominants in identified terpene compounds. Essential oil exhibited a significant antioxidant activity in ORAC test with moderate cytotoxic activity (80 ± 11 μg/ml) against lung carcinoma (A-549) cell line.


G. Çelik et al., ‘Biological activity, and volatile and phenolic compounds from five Lamiaceae species’, Flavour Fragr. J., vol. 36, no. 2, pp. 223–232, Mar. 2021, doi: 10.1002/ffj.3636.

O. Sytar, I. Hemmerich, M. Zivcak, C. Rauh, and M. Brestic, ‘Comparative analysis of bioactive phenolic compounds composition from 26 medicinal plants’, Saudi J. Biol. Sci., vol. 25, no. 4, pp. 631–641, May 2018, doi: 10.1016/j.sjbs.2016.01.036.

კუჭუხიძე ჯ., ჯოხაძე მ., ბოტანიკა (სამკურნალო მცენარეები). თბილისი, 2012.

L. R. Ramos da Silva et al., ‘Lamiaceae Essential Oils, Phytochemical Profile, Antioxidant, and Biological Activities’, Evid. Based Complement. Alternat. Med., vol. 2021, pp. 1–18, Dec. 2021, doi: 10.1155/2021/6748052.

B. Tohidi, M. Rahimmalek, and A. Arzani, ‘Essential oil composition, total phenolic, flavonoid contents, and antioxidant activity of Thymus species collected from different regions of Iran’, Food Chem., vol. 220, pp. 153–161, Apr. 2017, doi: 10.1016/j.foodchem.2016.09.203.

Morales, R, ‘The history, botany and taxonomy of the genus Thymus’, Taylor Francis Lond. U. K., 2002.

დავლიანიძე მ., ღვინიაშვილი ც., მუყბანიანი მ., ჯიჯოლია-იმნაძე ლ., ჯუღელი თ., საქართველოს ფლორის ნომენკლატურული ნუსხა. თბილისი, 2018.

საქართველოს ფლორა, vol. XI. თბილისი: მეცნიერება, 1987.

M. Nikolić et al., ‘Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils’, Ind. Crops Prod., vol. 52, pp. 183–190, Jan. 2014, doi: 10.1016/j.indcrop.2013.10.006.

S. Jarić, M. Mitrović, and P. Pavlović, ‘Review of Ethnobotanical, Phytochemical, and Pharmacological Study of Thymus serpyllum L.’, Evid. Based Complement. Alternat. Med., vol. 2015, pp. 1–10, 2015, doi: 10.1155/2015/101978.

S. Ivasenko et al., ‘Antimicrobial Activity of Ultrasonic Extracts of Two Chemotypes of Thymus serpyllum L. of Central Kazakhstan and their Polyphenolic Profiles’, Open Access Maced. J. Med. Sci., vol. 9, no. A, pp. 61–67, Jan. 2021, doi: 10.3889/oamjms.2021.5520.

J. Legault, K. Girard-Lalancette, D. Dufour, and A. Pichette, ‘Antioxidant Potential of Bark Extracts from Boreal Forest Conifers’, Antioxidants, vol. 2, no. 3, pp. 77–89, Jul. 2013, doi: 10.3390/antiox2030077.

A. Grenier, J. Legault, A. Pichette, L. Jean, A. Bélanger, and R. Pouliot, ‘Antioxidant, Anti-Inflammatory, and Anti-Aging Potential of a Kalmia angustifolia Extract and Identification of Some Major Compounds’, Antioxidants, vol. 10, no. 9, p. 1373, Aug. 2021, doi: 10.3390/antiox10091373.

H. Coté, M.-A. Boucher, A. Pichette, and J. Legault, ‘Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents’, Medicines, vol. 4, no. 2, p. 34, May 2017, doi: 10.3390/medicines4020034.

S. Oueslati, R. Ksouri, H. Falleh, A. Pichette, C. Abdelly, and J. Legault, ‘Phenolic content, antioxidant, anti-inflammatory and anticancer activities of the edible halophyte Suaeda fruticosa Forssk’, Food Chem., vol. 132, no. 2, pp. 943–947, May 2012, doi: 10.1016/j.foodchem.2011.11.072.

Teona Korkotadze; Dali Berashvili; Sopio Gokadze; Malkhaz Jokhadze; Malkhaz Getia; Ketevan Mchedlidze; Jean Legault; Vakhtang Mshvildadze. Chemical Composition and Biological Activity of Aerial Parts of Thymus Collinus Bieb. Growing in Georgia. Georgian Biomedical News 2023, 1 (4).

A. C. Figueiredo, J. G. Barroso, L. G. Pedro, and J. J. C. Scheffer, ‘Factors affecting secondary metabolite production in plants: volatile components and essential oils’, Flavour Fragr. J., vol. 23, no. 4, pp. 213–226, Jul. 2008, doi: 10.1002/ffj.1875.

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