Keywords
berberine
liquid-liquid extraction
Mahonia
anti-inflammatory
How to Cite
Abstract
The aim of the work was to study the introduced plant on the Black Sea coast of Adjara Mahonia bealei (Fort.) Carr. for the content of alkaloids. A comparative analysis of the quantitative yield of the total amounts of alkaloids isolated from the aerial organs of M. bealei, collected in the phase of active flowering, showed the advantage of the amount obtained from flowers - 2.48%. Based on the results of the HPLC analysis, it was concluded not only about the percentage of the main protoberberine and aporphine alkaloids, but also in which fractions, which alkaloid is dominant (in leaves, three bases dominate at once: berberine (27%), jatrorrhizine (23%), magnoflorin (18%), in branches and flowers - dominated by one base - berberine (50%) and palmatin (57%), respectively, the rest are present in the form of traces). The results of the preliminary investigation suggest that the alkaloid containing substances obtained from the aboveground vegetative organs of the plant demonstrate antioxidant and anti-inflammatory activities.
References
State Pharmacopoeia USSR XI (2),, 1990: 115,116, 124, 125, 577, 579, 585;
Georgian flora. Tbilisi: “Metsniereba“, 1983: 376;
Romanadze, M. Metreveli. Bioecology of genus Mahonia Nutt. species at Batumi Botanical Garden / S. 17th international conference: Environmental problems of the XXI century. Minsk, Collection of Proceedings Conf., 2017, v. 2, 42-43;
A. Makashvili – Botanical Dictionary, “Metsniereba“, 1991. P.48
Ji, X., Li, Y., Liu, H., Yan, Y., Li, J. Determination of the alkaloid content in different parts of some Mahonia plants by HPCE. Pharmaceutica Acta Helvetiae 2000, 74, 387–391).
He J.-M. & Mu Q. The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review. J. of Ethnopharmacology, 2015,175, 668–683.
Trees and shrubs of the Batumi Botanical Garden: an annotated list. Tbilisi, 2012, 184
Xiangying Zeng , Yulian Dong , Guoying Sheng , Xichang Dong , Xuehui Sun , Jiamo Fu. Isolation and structure determination of anti-influenza component from Mahonia bealei. J. Ethnopharmacology, 2006, 108(3), 317-319
Abdur Rauf1* and all. Berberine as a Potential Anticancer Agent: A Comprehensive Review. Molecules 2021, 26(23), 7368.
State Pharmacopoeia USSR XI(2), 1990: 115,116, 124, 125, 577, 579, 585.
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