Changes in T Lymphocyte Subpopulations in Various Types of Enteritis
Celiac disease is an immune-mediated inflammatory condition of the small intestine that occurs in genetically predisposed individuals and is triggered by anti-gluten antibodies. To diagnose celiac disease, an intestinal biopsy is recommended. The biopsy typically reveals an increased number of intraepithelial lymphocytes (IELs), crypt hyperplasia, and villous atrophy (classified as Marsh II and Marsh III). It is crucial to differentiate celiac disease from chronic lymphocytic duodenitis, as the latter may show only minimal villous atrophy, moderate crypt hyperplasia, and infiltration of the lamina propria by lymphocytes, plasma cells, and eosinophils. The primary distinguishing factor between the two conditions is the number of intraepithelial lymphocytes. Our research findings indicate that CD103 is the most sensitive marker for differentiating between chronic lymphocytic duodenitis and celiac disease. Additionally, CD103 proves to be the most sensitive marker for assessing various degrees of celiac disease.
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