Pseudoprotein-Based Bionanocomposites Containing Benzoyl Peroxide
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The development of new biomedical technologies provides an opportunity to introduce new methods of treatment in medicine. Among them, one of the interesting and promising is the technology of controlled/sustainable release and supply of peroxides and/or oxygen in hypoxia, to improve cell viability and tissues’ functions. Many diseases or medical procedures require increased oxygenation. Oxygen delivery can reduce cell apoptosis, necrosisand failure of tissue formation (especially during transplantation). The presented work deals with the preparation of new nanocomposites based on pseudoproteins with the purpose to provide delivery of oxygen in sustained/controlled release fashion. Among the numerous pseudoproteins previously obtained by us, two poly(ester amide)s labelled as 4F4 and 8L6 and made on the basis of natural α-amino acids phenylalanine and leucine were selected as biodegradable matrices for making the goal nanocomposites containing benzoyl peroxide as a source of oxygen. The influence of various factors on the fabrication of nanocomposites has been studied along with the stability of the obtained composites upon storage.
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