Endometrial metaplasia represents the transformation of glandular structures of the endometrium into other functionally and morphologically different tissue. The presence of endometrial metaplasias can be observed during other concomitant, both benign and malignant processes. Accordingly, endometrial metaplasia occurs separately or together with other histopathological changes. Different types of endometrial metaplasia are chosen, the most common of which is ciliary metaplasia. Determining the biological behavior and prognosis of a tumor is a very difficult process and requires the use of various technologies, sophisticated and specialized tools and techniques, which are also diagnostically inefficient. The AgNOR staining technique is quick and easy to perform. It can be performed on candles embedded in paraffin. The aim of our study was to evaluate the proliferative activity of endometrial metaplasias using AgNor technology. Based on the results of the study, it was revealed that the maximum proliferative activity was observed in cases of immature squamous cell metaplasia of the endometrium. AgNOR technology can be used in routine diagnostic practice as an aid to determine the proliferative activity of cells and, accordingly, the prognosis.
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