Peculiarities of the proliferative activity of the gallbladder mucosa in precancerous and cancerous pathologies detected by AgNOR technology
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Gallbladder carcinoma is the most common tumor of the biliary tract. Gallbladder carcinoma is asymptomatic in the initial stage, which complicates its detection and treatment. One of the risk factors for the development of gallbladder carcinoma is gallstone disease, which in turn leads to the development of a chronic inflammatory process. The chronic inflammatory process is determined by a continuous cycle of cell death and epithelial repair. The relationship between gallstone disease and gallbladder carcinoma has been established by many In particular, it has been shown that patients with gallstone disease have a 21% to 57% higher incidence of gallbladder carcinoma than those without gallstone disease. The aim of our study was to reveal the features of proliferative activity in different gallbladder nosologies in the presence and absence of chronic cholecystitis using AGNOR additional staining technology.
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