Peculiarities of the proliferative activity of the gallbladder mucosa in precancerous and cancerous pathologies detected by AgNOR technology


Gallbladder carcinoma
proliferative activity
prognostic markers

How to Cite

Kveliashvili, T., Didava, G., Tevzadze, N., Kepuladze, S., & Burkadze, G. (2023). Peculiarities of the proliferative activity of the gallbladder mucosa in precancerous and cancerous pathologies detected by AgNOR technology. Georgian Scientists, 5(4), 342–352.


Gallbladder carcinoma is the most common tumor of the biliary tract. Gallbladder carcinoma is asymptomatic in the initial stage, which complicates its detection and treatment. One of the risk factors for the development of gallbladder carcinoma is gallstone disease, which in turn leads to the development of a chronic inflammatory process. The chronic inflammatory process is determined by a continuous cycle of cell death and epithelial repair. The relationship between gallstone disease and gallbladder carcinoma has been established by many In particular, it has been shown that patients with gallstone disease have a 21% to 57% higher incidence of gallbladder carcinoma than those without gallstone disease. The aim of our study was to reveal the features of proliferative activity in different gallbladder nosologies in the presence and absence of chronic cholecystitis using AGNOR additional staining technology.


Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020 Jan 8;70(1):7–30.

Ryu S, Chang Y, Yun KE, Jung HS, Shin JH, Shin H. Gallstones and the Risk of Gallbladder Cancer Mortality: A Cohort Study. American Journal of Gastroenterology. 2016 Oct;111(10):1476–87.

Espinoza JA, Bizama C, García P, Ferreccio C, Javle M, Miquel JF, et al. The inflammatory inception of gallbladder cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2016 Apr;1865(2):245–54.

Pilgrim CHC, Groeschl RT, Christians KK, Gamblin TC. Modern perspectives on factors predisposing to the development of gallbladder cancer. HPB. 2013 Nov;15(11):839–44.

Roa I, de Aretxabala X, Araya JC, Roa J. Preneoplastic lesions in gallbladder cancer. J Surg Oncol. 2006 Jun 15;93(8):615–23.

Sun X, Kaufman PD. Ki-67: more than a proliferation marker. Chromosoma. 2018 Jun 10;127(2):175–86.

Metreveli, B., Gagua, D., Burkadze, G., & Kepuladze, S. (2023). Proliferative characteristics of eutopic and ectopic endometrium in adenomyosis using AgNOR technology. Georgian Scientists, 5(1), 59–71.

Tavdgiridze, N., Tevdorashvili, G., Kepuladze, S., & Burkadze, G. (2023). ASSESSMENT OF PROLIFERATIVE ACTIVITY OF IMMATURE OVARIAN TERATOMAS USING agnor TECHNOLOGY. Georgian Scientists, 5(1), 233–248.

Arveladze, G., Beriashvili, R., Kepuladze, S., & Burkadze, G. (2023). Evaluation of proliferative activity of different subtypes of basal cell carcinomas by AgNOR technology. Georgian Scientists, 5(4), 206–218.

Murgod S, Channabasaviah G, Shivamurthy D, Ashok L, Krishnappa S. Prognostic potential of AgNORs in oral submucous fibrosis. J Int Soc Prev Community Dent. 2016;6(2):167.

Barbakadze, L., Kintraia, N., Burkadze, G., & Kepuladze, S. (2023). ASSESSMENT OF PROLIFERATIVE ACTIVITY OF ENDOMETRIAL STROMAL TUMORS USING AgNOR TECHNOLOGY. Georgian Scientists, 5(2), 123–133.

Nishie H, Hirooka Y, Kaibara N. Argyrophilic nucleolar organizer regions of breast tumors: Assessment of aspirated cytological materials. Breast Cancer. 1996 Dec;3(3):199.

Chiu KY, Loke SL, Wong KK. Improved silver technique for showing nucleolar organiser regions in paraffin wax sections. J Clin Pathol. 1989 Sep 1;42(9):992–4.

Svanadze, T., Kepuladze, S., Tevzadze, N., & Burkadze, G. (2023). ASSESSMENT OF PROLIFERATIVE ACTIVITY OF DIFFERENT TYPES OF SQUAMOUS CELL METAPLASIA OF THE CERVIX USING AgNor TECHNOLOGY. Georgian Scientists, 5(2), 275–287.

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