Features of hormone receptor expression and proliferative-apoptotic characteristics in endometrial ciliary/tubal metaplasia

Metaplasia is an adaptive process in which one tissue is transformed into another tissue that is functionally and morphologically different. The most common type of metaplasia in the endometrium is ciliary/tubal metaplasia, which is also common in the cervix, where it is most often located in the transition zone. Ciliary metaplasia of the endometrium is often described in combination with excessive estrogen expression, and its association with simple and complex hyperplasia and highly differentiated adenocarcinoma is also worth noting. Overall, the study included a total of 315 unfixed formalin-fixed and paraffin-embedded (FFPE) cases (normal endometrium n=45; endometrial polyp n=45; simple endometrial hyperplasia n=45; complex endometrial hyperplasia n=45; atypical endometrial hyperplasia n=45). ; endometrioid carcinoma n=45; serous carcinoma n=45;). As can be seen from the data of our studies, ciliary metaplasia, as well as atypical ciliary metaplasia, is characterized by a different expression of estrogen receptors from the main research groups, which indicates hormone sensitivity independent of the main research nosology, which can also be evaluated as a justification for the existence of ciliary metaplasia independent of the main nosologies. As can be seen from the results, ciliary metaplasias show a different proliferative activity from the main study group, which should be taken into account in the algorithm for the evaluation of precancerous processes and tumors of endometrial hyperplasias. P16 can be used as an additional marker of possible progression of endometrial atypical hyperplasia to carcinoma in combination with other parameters.