Evaluation of proliferative activity of endometrial metaplasias by AgNor technology
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Endometrial metaplasia represents the transformation of glandular structures of the endometrium into other functionally and morphologically different tissue. The presence of endometrial metaplasias can be observed during other concomitant, both benign and malignant processes. Accordingly, endometrial metaplasia occurs separately or together with other histopathological changes. Different types of endometrial metaplasia are chosen, the most common of which is ciliary metaplasia. Determining the biological behavior and prognosis of a tumor is a very difficult process and requires the use of various technologies, sophisticated and specialized tools and techniques, which are also diagnostically inefficient. The AgNOR staining technique is quick and easy to perform. It can be performed on candles embedded in paraffin. The aim of our study was to evaluate the proliferative activity of endometrial metaplasias using AgNor technology. Based on the results of the study, it was revealed that the maximum proliferative activity was observed in cases of immature squamous cell metaplasia of the endometrium. AgNOR technology can be used in routine diagnostic practice as an aid to determine the proliferative activity of cells and, accordingly, the prognosis.
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Kaku T, Tsukamoto N, Tsuruchi N, Sugihara K, Kamura T, Nakano H. Endometrial metaplasia associated with endometrial carcinoma. Obstetrics and Gynecology. 1992;80(5):812–6.
Johnson TL, Kini SR. Endometrial metaplasia as a source of atypical glandular cells in cervicovaginal smears. Diagn Cytopathol. 1996 Feb;14(1):25–31.
Hendrickson MR, Kempson RL. The differential diagnosis of endometrial adenocarcinoma. Some viewpoints concerning a common diagnostic problem. Pathology. 1980;12(1):35–61.
Nicolae A, Preda O, Nogales FF. Endometrial metaplasias and reactive changes: A spectrum of altered differentiation. J Clin Pathol. 2011 Feb;64(2):97–106.
Wu P, Lv Q, Guan J, Shan W, Chen X, Zhu Q, et al. Clinical implications of morular metaplasia in fertility-preserving treatment for atypical endometrial hyperplasia and early endometrial carcinoma patients. Arch Gynecol Obstet. 2022 Oct 1;306(4):1135–46.
Travaglino A, Inzani F, Santoro A, Arciuolo D, Piermattei A, Pasquini S, et al. Endometrial Metaplastic/Reactive Changes Coexistent with Endometrial Hyperplasia and Carcinoma: A Morphological and Immunohistochemical Study. Diagnostics (Basel) [Internet]. 2021 Dec 28 [cited 2023 Jul 7];12(1). Available from: http://www.ncbi.nlm.nih.gov/pubmed/35054228
SVANADZE T, GACHECHILADZE M, BURKADZE G. PROBLEMATIC ISSUES IN THE EVALUATION OF MOLECULAR CHARACTERISTICS AND POTENTIAL NEOPLASTIC TRANSFORMATION OF CERVICAL METAPLASIA. EXPERIMENTAL & CLINICAL MEDICINE GEORGIA. 2021 Oct 11;
Metreveli B, Gagua D, Burkadze G, Kepuladze S. PROLIFERATIVE CHARACTERISTICS OF EUTOPIC AND ECTOPIC ENDOMETRIUM IN ADENOMYOSIS USING AgNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Jan 24 [cited 2023 May 14];5(1):59–71. Available from: https://journals.4science.ge/index.php/GS/article/view/1394
Tavdgiridze N, Tevdorashvili G, Kepuladze S, Burkadze G. ASSESSMENT OF PROLIFERATIVE ACTIVITY OF IMMATURE OVARIAN TERATOMAS USING AgNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Mar 21 [cited 2023 May 14];5(1):233–48. Available from: https://journals.4science.ge/index.php/GS/article/view/1567
Meshveliani P, Didava G, Tomadze G, Kepuladze S, Burkadze G. EVALUATION OF PROLIFERATIVE ACTIVITY OF PRE-TUMOR AND TUMOR PROCESSES OF BARRETT’S ESOPHAGUS USING AGNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Apr 23 [cited 2023 May 14];5(2):49–62. Available from: https://journals.4science.ge/index.php/GS/article/view/1687
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