Endometrial stromal sarcoma
Endometrial tumors
AgNOR count
Cell proliferation

How to Cite

Barbakadze, L., Kintraia, N., Burkadze, G., & Kepuladze, S. (2023). ASSESSMENT OF PROLIFERATIVE ACTIVITY OF ENDOMETRIAL STROMAL TUMORS USING AgNOR TECHNOLOGY. Georgian Scientists, 5(2), 123–133.


Endometrial stromal sarcomas (ESS) are rare neoplasms that arise from the endometrial stroma and account for less than 1% of all uterine malignancies. Diagnosis of ESS can be challenging due to its morphological overlap with other endometrial tumors, such as endometrial stromal nodules and stromal endometriosis. AgNOR count is a marker of cell proliferation and has been proposed as a potential tool for differentiating between different types of endometrial tumors.In this study, we analyzed the AgNOR count in 50 cases of endometrial tumors, including endometrial stromal nodules, stromal endometriosis, low-grade ESS, and high-grade ESS. Our results show that there is a significant difference in the AgNOR count across different types of endometrial tumors, with the mean AgNOR count increasing with the severity of the tumor. Endometrial stromal nodules had the lowest mean AgNOR count, while high-grade ESS had the highest.These findings suggest that AgNOR count may be a useful marker for differentiating between different types of endometrial tumors, including ESS. However, further research will be needed to confirm these findings and explore the clinical utility of this marker in the diagnosis and management of these conditions. Overall, our study contributes to our understanding of the biology of endometrial tumors and provides valuable information that may be useful in the development of diagnostic and treatment strategies for these conditions.


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