Features of the distribution of acute and chronic inflammatory index in cervical intraepithelial neoplasia of different degrees and its relationship with proliferative activity detected by AgNOR technology

Abstract

The microflora is the community of microbes that live in different organs. The relationship between the microbiome and inflammation is becoming increasingly clear. Moreover, the role of the microbiome and inflammation in cancer development and progression has been studied in many different studies. When the homeostasis of microorganisms is disturbed, the microorganisms themselves or their products cause counter-immune reactions in the macroorganism. As a result of prolonged inflammation, chronic inflammation develops, which is one of the inducing factors of cancer. Under conditions of chronic inflammation, cells are more prone to malignant transformation. Most studies have focused on the link between cervical cancer and the microbiome, although inflammation may also play a role in the development of cervical cancer. The aim of our study was to study the characteristics of the distribution of acute and chronic inflammatory indices in cervical intraepithelial neoplasia of different grades and to determine its relationship with the proliferative activity detected by AgNOR technology. From the inflammatory index, the higher the degree of dysplasia, the higher the chronic inflammatory index. The chronic inflammatory index can be used as an additional criterion for possible dysplasia. Additional AGNOR staining method may also be used to evaluate proliferative activity.