Detection of morphological changes in the Turkish hump structure in hyperprolactinemia caused by taking oral contraceptives

Abstract

 Hyperprolactinemia remains one of the most common neuroendocrine disorders today. It is manifested by an increase in the amount of the hormone prolactin in the peripheral blood and related changes. At the same time, some authors believe that taking combined estrogen-gestogen drugs in many cases causes such complications as prolactinomas. Published in 2005 four-year follow-up data on 2 groups of women: practically healthy, who took oral contraceptives and those with menstrual dysfunction. The observation was continued in the following years (2006-2019), on practically healthy women who received oral combined estrogen-gestogen preparations for contraception. 152 women were followed for one to three years at different points in time. An X-ray study of the Turkish humpback was performed while receiving high levels of prolactin in the peripheral blood. If necessary, computed tomography. In the first group, 85 women received oral combined estrogen-gestogenic preparations for one year continuously, in the second group 67 women, for more than one year continuously, for a maximum of 3 years.

1. In the first and second groups, a slight one-time increase in prolactin level was detected as a temporary reaction and adaptation to the drug.
2. A significant increase in prolactin level was detected in the first and second groups. It was recommended to stop the drug and to have a radiograph of the Turkish hump and additionally sent for a computed tomography. Morphological changes in the Turkish hump and pituitary structure were confirmed in 8 cases in both groups. Endocrinologist consultation and treatment were recommended.