Ключевые слова
metaplasia
proliferative activity
AgNOR
Как цитировать
Аннотация
Metaplastic processes represent the transformation of one type of cell into another type within the same tissue. It belongs to the group of adaptive-compensatory processes that develop in response to changed environmental conditions, hormonal stimulation or the development of inflammatory processes. Because its development is directly or indirectly accompanied by the tumorogenesis, they are considered as a pre-cancer condition with different potential for malignancy. The type of metaplasia depends on the type of target tissue itself. AgNOR/The Nucleolar Organizer Regions stands for Nucleolar Organizer Regions and are loops of DNA that project beneath the nucleolars of mitotic interphase nuclei. Increased amounts of AgNOR are associated with increased cell proliferation. The aim of the study was to evaluate the proliferative activity of different types of metaplasias of the cervix using AgNor technology. Based on the results of our research, we can assume that the mentioned technology can be used in routine practice as an aid to evaluate proliferative activity during cervical metaplastic processes.Библиографические ссылки
Hong SA, Yoo SH, Choi J, Robboy SJ, Kim KR. A Review and Update on Papillary Immature Metaplasia of the Uterine Cervix: A Distinct Subset of Low-Grade Squamous Intraepithelial Lesion, Proposing a Possible Cell of Origin. Arch Pathol Lab Med. 2018 Aug;142(8):973–81.
Hwang LY, Ma Y, Shiboski SC, Farhat S, Jonte J, Moscicki AB. Active squamous metaplasia of the cervical epithelium is associated with subsequent acquisition of human papillomavirus 16 infection among healthy young women. J Infect Dis. 2012 Aug 15;206(4):504–11.
Mockler D, Escobar-Hoyos LF, Akalin A, Romeiser J, Shroyer AL, Shroyer KR. Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia. Am J Clin Pathol. 2017 Sep 1;148(3):264–73.
SVANADZE T, GACHECHILADZE M, BURKADZE G. PROBLEMATIC ISSUES IN THE EVALUATION OF MOLECULAR CHARACTERISTICS AND POTENTIAL NEOPLASTIC TRANSFORMATION OF CERVICAL METAPLASIA. EXPERIMENTAL & CLINICAL MEDICINE GEORGIA. 2021 Oct 11;
Giroux V, Rustgi AK. Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence. Nat Rev Cancer. 2017 Oct;17(10):594–604.
Metreveli B, Gagua D, Burkadze G, Kepuladze S. PROLIFERATIVE CHARACTERISTICS OF EUTOPIC AND ECTOPIC ENDOMETRIUM IN ADENOMYOSIS USING AgNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Jan 24 [cited 2023 May 14];5(1):59–71. Available from: https://journals.4science.ge/index.php/GS/article/view/1394
Meshveliani P, Didava G, Tomadze G, Kepuladze S, Burkadze G. EVALUATION OF PROLIFERATIVE ACTIVITY OF PRE-TUMOR AND TUMOR PROCESSES OF BARRETT’S ESOPHAGUS USING AGNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Apr 23 [cited 2023 May 14];5(2):49–62. Available from: https://journals.4science.ge/index.php/GS/article/view/1687
Tavdgiridze N, Tevdorashvili G, Kepuladze S, Burkadze G. ASSESSMENT OF PROLIFERATIVE ACTIVITY OF IMMATURE OVARIAN TERATOMAS USING AgNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Mar 21 [cited 2023 May 14];5(1):233–48. Available from: https://journals.4science.ge/index.php/GS/article/view/1567
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