Study of inflammatory-fibrotic index of keloids and hypertrophic scars and features of proliferative activity of fibroblasts
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Wound healing is a physiological, complex, and well-regulated process involving a combination of cell migration, inflammation, innervation, and angiogenesis processes. Keloids (KS) and hypertrophic scars (HS) are formed as a result of damage to the epidermis and dermis. Although their exact pathogenesis is still not fully known, it is widely hypothesized that dysregulation of the molecular mechanisms involved in wound healing may lead to the formation of skin scars. Any deviation from the normal wound healing response can lead to excessive collagen accumulation and improper remodeling of the extracellular matrix (ECM), leading to the formation of a keloid or hypertrophic scar. The aim of our study was to study the characteristics of the distribution of inflammatory indices in dermatofibroma, keloid and hypertrophic scars, as well as to determine its relationship with the proliferative activity detected by AgNOR technology.
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