Phenotypic characteristics of recurrence and metastasis of endometrial epithelial tumors
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Endometrial carcinoma is a common gynecological malignancy, the incidence of which is increasing worldwide and accounts for 65,620 new cases annually. In Georgia, uterine tumors take the 3rd place in prevalence (13.3% per 100,000 women), and the 4th place in terms of mortality (4.8% per 100,000 women). Among endometrial carcinomas, endometrioid carcinomas are the most common, accounting for approximately 75-80% of endometrial malignant lesions. In recent years, there has been no significant improvement in the prognosis of endometrial carcinoma. It has also been shown that tumors that appear at an advanced stage with a high degree of malignancy and aggressive histopathological features are still common. Adjuvant therapeutic approaches today are still complex and contradictory, and there is only a small selection of treatment approaches for metastatic disease. Still, a significant difficulty is the reliable identification of the subgroup of patients who are at high risk of developing recurrence and metastases. The search for phenotypic characteristics of recurrence and metastasis of endometrial epithelial tumors is in an active phase, and there are no unambiguous data about them.
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