Challenges of Androgen Receptor Expression in Epithelial Tumors of the Breast and Ovary
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Breast cancer is the most common malignancy in women worldwide with more than 2.2 million newly diagnosed cases and more than 650,000 deaths annually. Triple-negative breast cancer accounts for 15-20% of all breast cancer cases and is characterized by aggressive behavior. Androgen receptor is considered as a possible new biomarker and potential therapeutic target in the treatment of breast cancer. Androgen receptor inhibitors may be considered a therapeutic option for specific subtypes of breast cancer. It plays a particularly important role in the carcinogenesis of triple-negative breast cancer. However, the issue of its active implementation in management is still controversial. Ovarian cancer is a gynecological malignancy diagnosed at an advanced stage in most cases and has different cellular origin, histological characteristics and therapeutic response. Epidemiological and experimental evidence suggests the involvement of androgens in the development of ovarian tumors. However, the influence of the androgen receptor in patients with epithelial ovarian tumors is still a subject of active study. Some studies have shown that androgen receptor overexpression is associated with good survival rates. There are also studies that show no significant association between steroid receptor expression and overall survival.
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