Molecular features of tubo-ovarian epithelial changes in ovarian epithelial tumours: Critical Review

Abstract

The etiology and pathogenesis of ovarian serous carcinomas as well as prognoses and clinical management are still under vigorous research. The data provided by many studies support the idea that ovarian serous carcinomas are mainly influenced by the changes occurring in the fallopian tube epithelium. This theory is supported by molecular lesions present in high-grade ovarian cancers and fallopian tube neoplasms. This topic needs some additional studies using pathogenetic characteristics like proliferative and apoptotic changes, which will further support and even may take it under suspicious the theory that ovarian carcinomas are originating from the fallopian tube. It is also crucial to study hormonal expressions while there is a lot of information that steroid hormones have a huge role in the pathogenesis of ovarian carcinomas but there is almost very little data on how these influences are related to the fallopian tube neoplasms. A deeper understanding of ovarian tumours and their etiological pathways are important to prevent and determine prognoses, which will enable better therapeutic methods. It has utmost importance to study additional characteristics like stem cell distribution in the fallopian tube epithelium and in ovarian neoplasms. The cancer heterogeneity need also further discussion regarding ovarian cancer novel classifications. This will finally aid the modification of better-personalized treatment.