Comparative analysis of the immunohistochemical expression of proliferation-apoptosis, epithelial-mesenchymal and hormone receptor markers in serous ovarian carcinoma and matched fallopian tube


Ovarian Cancer
Fallopian tube
Preinvasive lesions
Hormonal Receptors

How to Cite

Dzotsenidze , T., Gvenetadze , A., Gachechiladze , M. ., & Burkadze , G. (2022). Comparative analysis of the immunohistochemical expression of proliferation-apoptosis, epithelial-mesenchymal and hormone receptor markers in serous ovarian carcinoma and matched fallopian tube. Georgian Scientists, 4(3), 70–84.


During recent years, there is an accumulating evidence that high grade ovarian carcinoma is developed from the fallopian tube epithelial lesions. However, this subject is not completely understood and still represents the subject of investigation. We investigated the histopathological and immunohistochemical features of fallopian tubes from the patients with serous ovarian carcinoma. The results of our study indicate that in nearly 1/3 of the ovarian serous carcinoma cases, there is the presence of epithelial lesions in fallopian tubes, which might indicate the common origin. In addition, the expression of proliferation-apoptosis, epithelial-mesenchymal and hormone receptor markers are similar in nearly 1/3 of matched fallopian tube lesions and high grade serous ovarian carcinoma. Which represents additional evidence of the origin of high grade serous ovarian cancer from fallopian tube lesions.


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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2022 Tamar Dzotsenidze , Arsen Gvenetadze , Mariam Gachechiladze , George Burkadze


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