TRITERPENE SAPONINS OF SOME PLANTS GROWING IN GEORGIA AND THEIR BIOLOGICAL ACTIVITY

TRITERPENE SAPONINS OF SOME PLANTS GROWING IN GEORGIA AND THEIR BIOLOGICAL ACTIVITY

Authors

DOI:

https://doi.org/10.52340/gs.2023.05.02.05

Keywords:

Fatsia japonica, Bupleurum wittmannii, triterpene glycosides, saikosaponins, anti-inflammatory

Abstract

Triterpene saponins, which are widely distributed in the plant world, are characterized by versatile biological activity. They are characterized by diverse pharmacological activity  including, but not limited to immunostimulating, antitumor, antimutagenic, anti-inflammatory. The study reports the results of chemical study of glycosides obtained the sum of purified saponins (PS-551) from Fatsia japonica and Bupleurum B.wittmannii Stev. and from B. rotundifolium and their anti-inflammatory activity. Glycosides content in F.japonica  appeared 6.5%, in B.wittmannii Stev. - 3.4%, and in B.rotundifolium L. - 3.7%. Among the triterpene glycosides obtained from above-ground organs, saponins of the oleanol type were identified - saikosaponin A and saikosaponin C. In the model of carrageenan-induced edema in rodents, it was determined that all the investigated products exhibit a pronounced dose-dependent anti-inflammatory effect. In addition, the effective dose of glycosides of B.wittmannii Stev. was found to be twice more than that of B.rotundifolium and F. japonica, due to which B.wittmannii Stev. can be considered as a promising raw material rich in saikosaponins for the development of effective anti-inflammatory drugs.

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Author Biographies

Zurab Kemoklidze, Tbilisi State Medical University

Doctor of Pharmacy, Senior Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University

Marine Sulakvelidze, Tbilisi State Medical University

Senior Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University

Zhana Novikova, Tbilisi State Medical University

Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University

Karen Mulkijanyan, Tbilisi State Medical University

Principal Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University

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ზურაბ ქემოკლიძე - ფარმაციის დოქტორი, თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის უფროსი მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: z.qemoklidze@tsmu.edu

მარინე სულაქველიძე - თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის უფროსი მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: m.sulakvelidze@tsmu.edu

ჟანა ნოვიკოვა - თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: z.novikova@tsmu.edu

კარენ მულკიჯანიანი - თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის მთავარი მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: k.mulkijanyani@tsmu.edu

Zurab Kemoklidze1 - Doctor of Pharmacy, Senior Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, E-mail: z.qemoklidze@tsmu.edu

Marina Sulakvelidze 2 - Senior Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, m.sulakvelidze@tsmu.edu

Zhana Novikova3- Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, z.novikova@tsmu.edu

Karen Mulkijaniani 4-Principal Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, k.mulkijanyani@tsmu.edu

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Published

2023-04-12

How to Cite

Kemoklidze, Z., Sulakvelidze, M., Novikova, Z., & Mulkijanyan, K. (2023). TRITERPENE SAPONINS OF SOME PLANTS GROWING IN GEORGIA AND THEIR BIOLOGICAL ACTIVITY. GEORGIAN SCIENTISTS, 5(2), 32–40. https://doi.org/10.52340/gs.2023.05.02.05

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