TRITERPENE SAPONINS OF SOME PLANTS GROWING IN GEORGIA AND THEIR BIOLOGICAL ACTIVITY
DOI:
https://doi.org/10.52340/gs.2023.05.02.05Keywords:
Fatsia japonica, Bupleurum wittmannii, triterpene glycosides, saikosaponins, anti-inflammatoryAbstract
Triterpene saponins, which are widely distributed in the plant world, are characterized by versatile biological activity. They are characterized by diverse pharmacological activity including, but not limited to immunostimulating, antitumor, antimutagenic, anti-inflammatory. The study reports the results of chemical study of glycosides obtained the sum of purified saponins (PS-551) from Fatsia japonica and Bupleurum B.wittmannii Stev. and from B. rotundifolium and their anti-inflammatory activity. Glycosides content in F.japonica appeared 6.5%, in B.wittmannii Stev. - 3.4%, and in B.rotundifolium L. - 3.7%. Among the triterpene glycosides obtained from above-ground organs, saponins of the oleanol type were identified - saikosaponin A and saikosaponin C. In the model of carrageenan-induced edema in rodents, it was determined that all the investigated products exhibit a pronounced dose-dependent anti-inflammatory effect. In addition, the effective dose of glycosides of B.wittmannii Stev. was found to be twice more than that of B.rotundifolium and F. japonica, due to which B.wittmannii Stev. can be considered as a promising raw material rich in saikosaponins for the development of effective anti-inflammatory drugs.
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ზურაბ ქემოკლიძე - ფარმაციის დოქტორი, თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის უფროსი მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: z.qemoklidze@tsmu.edu
მარინე სულაქველიძე - თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის უფროსი მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: m.sulakvelidze@tsmu.edu
ჟანა ნოვიკოვა - თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: z.novikova@tsmu.edu
კარენ მულკიჯანიანი - თსსუ იოველ ქუთათელაძის ფარმაკოქიმიის ინსტიტუტის მთავარი მეცნიერ თანამშრომელი, საქართველო, თბილისი, E-mail: k.mulkijanyani@tsmu.edu
Zurab Kemoklidze1 - Doctor of Pharmacy, Senior Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, E-mail: z.qemoklidze@tsmu.edu
Marina Sulakvelidze 2 - Senior Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, m.sulakvelidze@tsmu.edu
Zhana Novikova3- Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, z.novikova@tsmu.edu
Karen Mulkijaniani 4-Principal Researcher, Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi, Georgia, k.mulkijanyani@tsmu.edu
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