BIOLOGICALLY ACTIVE ALKALOIDS OF SOME SPECIES OF PLANTS WIDESPREAD IN GEORGIA

Alkaloids Taxus baccata Thalictrum bushianum Peganum harmala cytotoxic activity melanoma

Authors

  • Lali Kintsurashvili Institute of Pharmacochemistry I. Kutateladze Tbilisi State Medical University, Georgia
  • Tamar Suladze Institute of Pharmacochemistry I. Kutateladze Tbilisi State Medical University, Georgia
  • Giorgi Jgerenaia Institute of Pharmacochemistry I. Kutateladze Tbilisi State Medical University, Georgia
  • Lasha Mskhiladze Institute of Pharmacochemistry I. Kutateladze Tbilisi State Medical University, Georgia

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The objects of research were: Taxus baccata L.- European yew(needles), Thalictrum bushianum Kem-Nath.- Meadow rue (underground parts), Peganum harmala L.- Wild rue (seeds). Biologically active substance of alkaloid row were obtained by liquid-liquid extraction metod. Phytochemical and in vitro studies on the sum of the alkaloids, obtained from above mentioned studying objects, have determined the activity against human melanoma cells (A2058).

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