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Abstract
Heracleum is one of the greatest genera of the Umbelliferae family that has more than 120 species. This genus is represented by 25 species in the Caucasus and by 23 species in Georgia. The photoallergic properties of Heracleum are connected with the presence of furanocoumarins. The genus Heracleum is a famous origin of furanocoumarins: bergapten, byakangelicol, phellopterin, xanthotoxin, isopimpinellin, and imperatorin, which show biological effects of a broad spectrum: antibacterial, antimicrobial, fungicidal, antioxidant, anti-inflammatory, anti-cancer. Also, they are significant drugs in vitiligo and psoriasis treatment. Dermatophytes have the capacity to invade keratinized tissues, producing dermatophytosis. Dermatophytosis ranks among the most common and widespread infectious diseases worldwide, and Trichophyton rubrum and Trichophyton mentagrophytes, which cause infections of skin and nails, are two of the most frequently isolated dermatophytes. Dermatophytes that cause lesions in nails do not respond well to treatment. This leads to the need to find new and more effective drugs. The aim of our research was to study the phytochemistry and antimicrobial activity of Heracleum sosnowskyi. HPLC-ESI-QTOF-MS/MS analyses showed that the methanolic extract of the underground and over-ground parts of Heracleum contains simple coumarins and furanocoumarins. While the tests conducted on dermatophytes – T. mentagrophytes and T. rubrum proved that Heracleum sosnowskyi can be considered as a potential source for the treatment of dermatophytosis.
References
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