How to Cite
Abstract
The aim of the present study was to develop optimal conditions for qualitative and quantitative analysis of some color agents (dyes) in solid drug forms. It is necessary to develop methods of analysis of high sensitivity and accuracy for the analysis of dyes, as they have certain regulations and analysis methods are not found in the available literature. Optimal conditions for isolation of tartrazine from tablet (solvent system - ethyl alcohol 50%), double isolation for 10 minutes) are developed, which provides effective isolation from tartrazine tablet (degree of isolation 93%). Optimal conditions of liquid chromatographic-tandem mass spectrometric method of qualitative-quantitative analysis of tartrazine in the tablet are developed. Rolling phase 0.1% formic acid: Acetonitrile - 0.1% formic acid: water (60:40), system isocratic, column temperature - 30o C, collision energy 100 EV, ionization positive (ESI +), multi-reaction monitoring mode (MRM). Validity parameters are set, the method is distinguished by linearity (caliber concentration 100.0 - 1000.0 ng / ml, correlation coefficient - R2 = 0.9984), selectivity, low detection minimum (100.23 ng / ml) and determinable minimum (201.68 ng / ml).
References
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