STUDY OF ALKALOIDS OF STENBERGIACOLCHICI FLORA WALDST & KITCULTIVATED IN GEORGIA

Abstract

The aim of the present research was to study the familyAmaryllidaceae, a species – Sternbergia colchiciflora, grow-ing in Georgia in particular, on the content of biologicallyactive substances such as alkaloid Galanthamine.Medicinal plants play an important role in the develop-ment of medicine. Nowadays, an alkaloid from the Amarylli-daceae family – Galanthamine due to its acetylcholinesteraseinhibitory action is very important in mild to moderate formsof Alzheimer’s disease.Using modern research methods (GS-MS, LC-MS), it wasconfirmed that the bulbs and leaves of Sternbergia colchici-flora cultivated in Georgia, which we studied, are raw materi-als rich with the alkaloid Galanthamine. Furthermore, Galan-thine, Lycorine, Tazettine and other alkaloids of the Amaryllisfamily are found in the plant.Nowadays, due to the scarcity of galantamine resources,finding new sources is a topical problem in Pharmacy, socomplete specification of areas for distribution of an alterna-tive source of Galanthamine, Sternbergia colchiciflora, fur-ther conservation of these areas and cultivation of new pop-ulations is a prerequisite for the survival of the endangeredspecies and the expansion of the base in the future.