Аннотация
Heracleum is one of the greatest genera of the Umbelliferae family that has more than 120 species. This genus is represented by 25 species in the Caucasus and by 23 species in Georgia. The photoallergic properties of Heracleum are connected with the presence of furanocoumarins. The genus Heracleum is a famous origin of furanocoumarins: bergapten, byakangelicol, phellopterin, xanthotoxin, isopimpinellin, and imperatorin, which show biological effects of a broad spectrum: antibacterial, antimicrobial, fungicidal, antioxidant, anti-inflammatory, anti-cancer. Also, they are significant drugs in vitiligo and psoriasis treatment. Dermatophytes have the capacity to invade keratinized tissues, producing dermatophytosis. Dermatophytosis ranks among the most common and widespread infectious diseases worldwide, and Trichophyton rubrum and Trichophyton mentagrophytes, which cause infections of skin and nails, are two of the most frequently isolated dermatophytes. Dermatophytes that cause lesions in nails do not respond well to treatment. This leads to the need to find new and more effective drugs. The aim of our research was to study the phytochemistry and antimicrobial activity of Heracleum sosnowskyi. HPLC-ESI-QTOF-MS/MS analyses showed that the methanolic extract of the underground and over-ground parts of Heracleum contains simple coumarins and furanocoumarins. While the tests conducted on dermatophytes – T. mentagrophytes and T. rubrum proved that Heracleum sosnowskyi can be considered as a potential source for the treatment of dermatophytosis.
Библиографические ссылки
კუჭუხიძე ჯ., გაგნიძე რ., ღვინიაშვილი ც., ჯოხაძე მ. საქართველოს ფლორის ენდემური ყვავილოვანი მცენარეები, თბილისი, 2016. გვ. 40-46. 2. Arendrup MC, Kahlmeter G, Guinea J, Meletiadis J; Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). How to: perform antifungal susceptibility testing of microconidia-forming dermatophytes following the new reference EUCAST method E.Def 11.0, exemplified by Trichophyton. Clin Microbiol Infect. 2021 Jan;27(1):55-60. doi: 10.1016/j.cmi.2020.08.042. Epub 2020 Sep 8. PMID: 32916260
Barros MEDS, Santos DA, Hamdan JS. Evaluation of susceptibility of Trichophyton mentagrophytes and Trichophyton rubrum clinical isolates to antifungal drugs using a modified CLSI microdilution method (M38-A). J Med Microbiol. 2007 Apr;56(Pt 4):514-518. doi: 10.1099/jmm.0.46542-0. PMID: 17374893.
Bhatnagar, A.; Kanwar, A.; Parsad, D.; De, D. (2007). Psoralen and ultraviolet A and narrow band ultraviolet B in inducing stability in vitiligo, assessed by vitiligo disease activity score: an open prospective comparative study. Journal of the European Academy of Dermatology and Venereology, 21(10), 1381-1385.
El Fari, M., Tietz, H. J., Presber, W., Sterry, W. & Graser, Y. (1999). Development of an oligonucleotide probe specific for Trichophyton rubrum. Br J Dermatol 141, 240–245
Favre, B., Hofbauer, B., Hildering, K. & Ryder, N. S. (2003). Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay. J Clin Microbiol 41, 4817–4819
Hosseinzadeh, Z., Ramazani, A., & Razzaghi-Asl, N. (2019). Plants of the Genus Heracleum as a Source of Coumarin and Furanocoumarin. Journal of Chemical Reviews, 1(2), 78-98.
Œliwiñski M. Inwazyjne gatunki roœlin ekosystemów mokrad owych Polski. Dajdok Z., Pawlaczyk P. (Ed.). Wydawnictwo Klubu Przyrodników. Œwiebodzin, 2009; 54-57.
Jakubska-Busse, A., Œliwiñski, M., & Kobyka, M. (2013). Identification of bioactive components of essential oils in Heracleum sosnowskyi and Heracleum mantegazzianum (Apiaceae). Archives of Biological Sciences, 65(3), 877-883.
Miklaszewska K. Barszcz Sosnowskiego – obcy gatunek inwazyjny: biologia, zagro¿enia, zwalczanie. Prog Plant Protection/Post Ochr Roœlin 2008; 48(1): 297-300.
Mishyna, M.; Laman, N.; Prokhorov, V.; Fujii, Y. (2015). Angelicin as the principal allelochemical in Heracleum sosnowskyi fruit. Natural product communications, 10(5), 767-770.
Oliwia Jakubowicz, Czesaw aba, Gerard Nowak, Stanis aw Jarmuda, Ryszard ¯aba, Jerzy T. Marcinkowski. Heracleum sosnowskyi Manden. Annals of Agricultural and Environmental Medicine 2012, Vol 19, No 2
POWO (2022). “Plants of the World Online. Facilitated by the Royal Botanic Gardens, Kew. Published on the Internet
Roberts, D. T., Taylor, W. D. & Boyle, J. (2003). Guidelines for treatment of onychomycosis. Br J Dermatol 148, 402–410
Shakhmatov, E. G.; Toukach, P. V.; Kuznetsov, S. P.; Makarova, E. N. (2014). Structural characteristics of watersoluble polysaccharides from Heracleum sosnowskyi Manden. Carbohydrate polymers, 102, 521- 528
Strzelecka H, Kowalewski J. Encyklopedia zielarstwa i zioolecznictwa. Wydawnictwo PWN, Warszawa, 2000. http://www.plantsoftheworldonline.org/Retrieved 24 November2022.
Trott, J.; Gerber, W.; Hammes, S.; Ockenfels, H.-M. (2008). The effectiveness of PUVA treatment in severe psoriasis is significantly increased by additional UV 308- nm excimer laser sessions. European Journal of Dermatology, 18(1), 55-60
Wojtkowiak R, Kawalec H, Dubowski AP. Heracleum Sosnowskyi Mandel L. J Res Appl Agric Eng. 2008; 53(4): 137-142.