DEVERGIE’S DISEASE – CLINICAL CASE

DEVERGIE’S DISEASE – CLINICAL CASE

Authors

  • IRAKLI KUTALIA
  • KETO GIGINEISHVILI
  • DAVIT KAKULASHVILI
  • ALEXANDER KATSITADZE
  • NATO KORSANTIA

DOI:

https://doi.org/10.52340/jecm.2025.06.27

Keywords:

Pityriasis rubra pilaris, Devergie’s disease, Follicular hyperkeratosis, CARD14 mutation

Abstract

Devergie’s disease (pityriasis rubra pilaris – PRP) is an idiopathic inflammatory, papulosquamous dermatosis. Clinically, it is characterized by disordered keratinization and the formation of hyperkeratotic follicular papules that coalesce into the orange-red plaques, between these areas the skin is not changed “islands of sparing” - are observed. Possible associations include infectious diseases, autoimmune processes, medication-induced reactions, and malignant neoplasms.

The article describes a clinical case of Devergie’s disease. Patient S.E., 56 years old. 26.04.25, “Kani Clinic.” The patient complained of a generalized skin rash. General condition: satisfactory. On the trunk, upper, and lower extremities, numerous, separately distributed, orange-colored hyperkeratotic follicular papules were noted. On the extensor surface of the upper extremity, a solitary plaque was present.

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References

DermNet NZ. Pityriasis rubra pilaris. https://dermnetnz.org

Griffiths W.A. Pityriasis rubra pilaris: The Griffiths classification. ClinExpDermatol. 1980;5(1):105–112.

Gao Q., Sun L.D., Liu Y. et al. Genetic variants in CARD14 confer susceptibility to pityriasis rubra pilaris. Nat Genet. 2012;44(7):745–748.

Miralles ES, et al. Pityriasis rubra pilaris and human immunodeficiency virus infection. Br J Dermatol 1995; 133: 990

Ross N.A., Chung H.J., Li Q., Andrews J.P. Pityriasis rubra pilaris: A comprehensive review. J Am Acad Dermatol. 2016;75(1):165–181.

Vañó-Galván S., Molina-Ruiz A.M., Vicente-Martín F.J. Pityriasis rubra pilaris: Update and review of management options. Am J Clin Dermatol. 2017;18(3):377–397.

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Published

2025-12-06

How to Cite

KUTALIA, I., GIGINEISHVILI, K., KAKULASHVILI, D., KATSITADZE, A., & KORSANTIA, N. (2025). DEVERGIE’S DISEASE – CLINICAL CASE. Experimental and Clinical Medicine Georgia, (6), 157–160. https://doi.org/10.52340/jecm.2025.06.27

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