SURFACTANT (SP-D) AND LUNG FUNCTIONAL DATA RELATIONSHIP WITH ECHOCARDIOGRAPHIC INDICATORS OF HEART ISCHEMIC AND CHRONIC OBSTRUCTIVE PULMONARY DISEASES

Abstract

Background: As it is well-known, cardio-vascular diseases represent one of the leading causes of mortality. This disease is frequently accompanied by the chronic obstructive pulmonary disease which extremely complicates the patient’s outcomes resulting in the increase of mortality rate. The conducted study reviews the effect of SP-D upon the coronary heart disease and chronic obstructive pulmonary disease and evaluates its relationships with the changes of echocardiographic parameters in case of the concomitant existence of these two diseases.

Methods: The cohort of 90 patients were included in the study. The patients were divided into five groups: group I (patients with CHD); group II (patients with dyslipidemia); group III (patients with COPD); group IV (patients with CHD and COPD); group V (control group). For the purpose of inclusion of patients in the above-mentioned groups, the study utilized the laboratory (dyslipidemia - enzymatic methods) as well as the instrumental methods (echocardiography, the pulmonary function tests were determined through spirometry test).

Results: The highest incidence of SP-D was identified in the group of combined CHD and COPD (35,1±16,7); The high value of circulated SP-D, which statistically differed from other groups, clearly illustrated its effect on the clinical condition of a patient in case of COPD and CHD combination, when there was detected the pulmonary function impairment FEV1-56.2±12.7, FVC-61.2±11.4 and FEV1/FVC 0.709±0.10 as well as the positive correlation between SP-D and FEVI indicating the exacerbation of obstruction during the concomitant CHD. According to the present study, the changes were observed in the echocardiographic data, namely, the reduced ejection fraction (EF%) in the IV – combined CHD and COPD group and the increased ventricular size in the same group. Conclusion: In COPD, the left ventricular functions as well as the right ventricle are impaired prior to the distinct clinical manifestation of heart disease and the echocardiographic parameters are in correlation with the functional parameters of COPD patients.