COVID INFECTION AND GUILLAN-BARRE SYNDROME
Keywords:COVID-19, Guillan-Barre syndrome
Introduction. For three years COVID-19 has been raging in Georgia as well as all over the world. Many clinics including ours have become a battle place against covid infection.
The aim of this work is to introduce interesting clinical cases which are related to covid infection associated Guillain-Barre syndrome and to find ways of prevention.
Materials and methods. We have studied patients with covid infection in our clinic from October 2020 to February 2021. In total 544 patients were admitted to the clinic, 477 were treated on a stationary basis. Among them 242 were men and 240 – women, the median age was 47 years. In the post-covid period 270 patients were re-admitted to clinic within two weeks to three months. Among them only 3 had Guillan-Barre disease (GBS). All the patients had a Brighton criteria level of diagnostic certainty 1 or 2.
Results and conclusion. As COVID 19 is an easily contagious disease which caused the worst pandemic in the 21st century, it is important to pay attention to patients whose first signs may be neurological symptoms. Diagnosis at the early stage of the disease will be important to manage correctly and prevent its spread. Disease prevention means applying to the hospital on time, because disease course directly depends on relevant examination and treatment.
Lu H., Stratton C.W., Tang Y.W. Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle. J Med Virol. 2020 doi: 10.1002/jmv.25678. Epub ahead of print.
Zhao Y, Zhao Z, Wang Y, et al. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. bioRxiv 2020, published online 26 January. doi: 10.1101/2020.01.26.919985.
Wang W., Tang J., Wei F. Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China. J Med Virol. 2020;92(4):441–447. doi: 10.1002/j
Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395:507–513. doi: 10.1016/S0140-6736(20)30211-7
Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)3018
Chen L, Liu HG, Liu W, Liu J. Liu K. et al. Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 2020; 43(0): E005. https://doi.org/10.3760/cma.j.issn.1001-0939.2020.0005. [Epub ahead of print]
Wang D., Hu B., Hu C., Zhu F., Liu X., et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 doi: 10.1001/jama.2020.1585. [Epub ahead of print
Mao L, Wang M, Chen Sh, He Q, Chang J, Hong C, et al. Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: A Retrospective Case Series Study (February 24, 2020). Available at SSRN: https://ssrn.com/abstract=3544840
Sahin AR, Erdogan A, Mutlu Agaoglu P, Dineri Y, Cakirci AY, Senel ME, et al. 2019 Novel Coronavirus (COVID-Outbreak: A Review of the Current Literature. EJMO 2020;4(1):1-7.14.