ERUPTIVE XANTHOMATOSIS - CLINICAL CASE

NATO KORSANTIA; ALEXANDER KATSITADZE; NINO TSISKARISHVILI; NINO ADAMASHVILI; TAMAR GOGINASHVILI; MAKA BIBICHADZE; NINO KORSANTIA

doi:10.52340/jecm.2023.06.04

ERUPTIVE XANTHOMATOSIS - CLINICAL CASE

Authors

NATO KORSANTIA Tbilisi State Medical University
ALEXANDER KATSITADZE Tbilisi State Medical University
NINO TSISKARISHVILI Tbilisi State Medical University
NINO ADAMASHVILI Tbilisi State Medical University
TAMAR GOGINASHVILI Tbilisi State Medical University
MAKA BIBICHADZE Tbilisi State Medical University
NINO KORSANTIA Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2023.06.04

Keywords:

Eruptive Xanthomas, Metabolic Disorders, Diabetes mellitus, Hyperlipidemia

Abstract

Eruptive xanthomas are rare and often asymptomatic. On the other hand, these cutaneous lesions are signs for serious underlying metabolic disorders that demand an early diagnosis to prevent morbidity and mortality. We report on one male patient, aged 32 years, who presented with eruptive xanthomas. Treatment was tailored according to underlying pathologies and resulted in significant improvement of the metabolic parameters and improvement of skin lesions. Dermatologists should be aware of the diagnostic importance of eruptive xanthomas for serious metabolic disorders.

Downloads

Download data is not yet available.

References

Zak A, Zeman M, Slaby A, Vecka M. Xanthomas: clinical and pathophysiological relations. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014;158(2):181–8.

Smith KJ, Yeager J, Skelton HG. Histologically distinctive papular neutrophilic xanthomas in HIV-1+patients. Am J Surg Pathol. 1997;21(5):545–9.

Santiago L, Pinho A, Cardoso JC. Eruptive xanthomas: a cardinal manifestation of the serious metabolic disease. Acta Med Port. 2018;31(4):219–22.

Zabeen B, Khaled Z, Nahar J, Baki A, Amin F, Akhter S, Begum T, Azad K, Nahar N. Hypertriglyceridemia associated with eruptive xanthomas and lipemia retinalis in newly diagnosed diabetes mellitus. Mymensingh Med J. 2013;22(3):591–5. PMid:23982556.

Brazzelli V, Rivetti N, Carugno A, Barruscotti S, Croci GA, Perani G, Borroni G. Eruptive xanthomas after extensive tattooing: a case report and literature review. G Ital Dermatol Venereol. 2015;150(6):770–1.

Gao H, Chen J. Eruptive xanthomas presenting in tattoos. CMAJ. 2015;187(5):356.

Saraceno R, Dattola A, Pietroleonardo L, Pitocco R, Fida M, Chimenti S. Eruptive xanthomas and pancreatitis: clinical, dermatoscopy, confocal and pathological correlation. G Ital Dermatol Venereol. 2017;152(4):394–6.

Seremet S, Gurel MS. Miscellaneous skin disease and the metabolic syndrome. Clin Derm 2018;36(1):94–100.

Machado PV, Daxbacher EL, Obadia DL, Cunha EF, Alves Mde F, Mann D. Do you know this syndrome? Berardinelli-Seip syndrome. An Bras Dermatol. 2013;88(6):1011–3.

Zakon SJ, Oyamada A, Rosenthal IH. Eruptive xanthoma and hyperlipemia in glycogen storage disease (von Gierke's disease) AMA Arch Derm Syphilol. 1953;67(2):146–51.

Gagné C, Brun LD, Julien P, Moorjani S, Lupien PJ. Primary lipoprotein-lipase-activity deficiency: clinical investigation of a French-Canadian population. CMAJ. 1989;140(4):405–11.

Giry C, Giroux LM, Roy M, Davignon J, Minnich A. Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas. J Lipid Res. 1996;37(7):1422–35. PMid:8827515.

Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar J, Kruth H, Rader DJ. Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ Res. 2015;116(5):789–96.

Ye Q, Lei H, Fan Z et al. Difference in LDL receptor feedback regulation in macrophages and vascular smooth muscle cells: foam cell transformation under inflammatory stress. Inflammation. 2014;37(2):555–65.

Wollina U, Koch A, Hansel G, Schönlebe J. Eruptive Xanthomas - Two Case Reports With Distinct Features. Open Access Maced J Med Sci. 2018 Nov 21;6(11):2152-2154.