FAMILY HERPESVIRIDAE – AN OVERVIEW

FAMILY HERPESVIRIDAE – AN OVERVIEW

Authors

DOI:

https://doi.org/10.52340/jecm.2024.01.04

Keywords:

Herpes, Herpesviridae, chickenpox, Epstein-Barr, Kaposi sarcoma

Abstract

SUMMARY

Herpesviruses (family Herpesviridae) are large, enveloped viruses that possess a linear double-strand DNA of 120–240 kb. Eight human herpesviruses were discovered, which are subdivided into three genera: alpha-, beta- and gamma-herpesvirus. Herpesvirus infections cause significant morbidity in AIDS and organ transplant patients with compromised immune systems.

After initial infection, all herpesviruses remain latent within specific host cells and may subsequently reactivate. Clinical syndromes due to primary infection can vary significantly from those caused by reactivation of these viruses. Herpesviruses do not survive long outside a host; thus, transmission usually requires intimate contact. In people with latent infection, the virus can reactivate without causing symptoms; in such cases, asymptomatic shedding occurs and people can transmit infection.

Despite the fact that the herpesviruses are genetically and structurally similar, they cause a wide array of generally non-overlapping clinical syndromes.

In contrast to other herpesviruses that are not known to cause malignancy, Epstein-Barr virus (EBV) and human herpesvirus type 8 (HHV-8), also known as Kaposi sarcoma–associated herpesvirus (KSHV), can cause certain cancers.

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References

Wang-Shick Ryu, Molecular Virology of Human Pathogenic Viruses. 2017 https://doi.org/10.1016/B978-0-12-800838-6.00009-6]

Kenneth M.Kaye - Overview of herpesvirus infections. Infectious diseases - MSD manual professional edition. 2023. https://www.msdmanuals.com/professional/infectious-diseases/herpesviruses/overview-of-herpesvirus-infections

Guess HA, Broughton DD, Melton LJ 3rd, Kurland LT. Population-based studies of varicella complications. Pediatrics 78(4 Pt 2):723-727, 1986.

Committee on Infectious Diseases, American Academy of Pediatrics. Red Book: 2021 – 2024 Report of the Committee on Infectious Diseases. 32nd ed. American Academy of Pediatrics; 2021

Centers for disease control and prevention: child and adolescent immunization schedule by age, Nov.2023. https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html

Yawn BP, Wollan PC, Kurland MJ, St Sauver JL, Saddier P. Herpes zoster recurrences more frequent than previously reported. Mayo Clin Proc 86(2):88-93, 2011. doi:10.4065/mcp.2010.0618

Dooling KL, Guo A, Patel M, et al. Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines. MMWR Morb Mortal Wkly Rep 2018;67:103–108. DOI: http://dx.doi.org/10.15585/mmwr.mm6703a5

Anderson TC, Masters NB, Guo A, et al. Use of Recombinant Zoster Vaccine in Immunocompromised Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022. MMWR Morb Mortal Wkly Rep 2022;71:80–84. DOI: http://dx.doi.org/10.15585/mmwr.mm7103a2

USA Food and Drug Administration. FDA Requires a Warning about Guillain-Barré Syndrome (GBS) be Included in the Prescribing Information for Shingrix. FDA Safety Communication - March 24, 2021

Lal H, Cunningham AL, Godeaux O et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med 372(22):2087-96, 2015. Epub 2015 Apr 28. PMID: 25916341. doi: 10.1056/NEJMoa1501184

Johannsen EC, Kaye KM: Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases). In Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Ninth Edition), Elsevier, 2020, pp. 138, 1872-1890, 2020. ISBN: 9996119890, 9789996119897

Brenda L. Tesini, Congenital and perinatal Cytomegalovirus Infection (CMV). MSD manual professional edition. Sep. 2022. https:/www.msdmanuals.com/professional/pediatrics/infections-in-neonates/congenital-and-perinatal-cytomegalovirus-infection-cmv

Staras SA, Dollard SC, Radford KW et al. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis 43(9):1143-1151, 2006. doi:10.1086/508173

Sugar RA, Jabs DA, Ahuja A et al. Incidence of cytomegalovirus retinitis in the era of highly active antiretroviral therapy. Am J Ophthalmol 153(6):1016-24.e5, 2012. doi:10.1016/j.ajo.2011.11.014

Michael M. Wolz; Gabriel F. Sciallis; and Mark R. Pittelkow. Human Herpesviruses 6, 7, and 8 From a Dermatologic Perspective. Mayo Foundation for Medical Education and Research. Mayo Clin Proc. 2012;87(10):1004-1014

Prober CG. Human herpesvirus 6. Adv Exp Med Biol. 2011; 697:87-90

Flamand L, Komaroff AL, Arbuckle JH, Medveczky PG, Ablashi DV. Review, part 1: human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy. J Med Virol. 2010;82(9): 1560-1568.

Anthony L. KOmaroff, Danielle M. Zerr, Louis Flamand. Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7. Journal of Medical Virology. 2019. https://doi.org/10.1002/jmv.25576]

Nato korsantia, Al.Katsitadze, N.Kiladze, N.Tsiskarishvili et al. Pityriasis Rosea Gibert and Herpes Simplex – Clinical Case. Journal of Experimental and Clinical Medicine. Tbilisi. Georgia. 2021; 2: 31-35

Cohen JI, Dropulic L, Hsu AP et al. Association of GATA2 deficiency with severe Epstein-Barr virus (EBV) infection and EBV-associated cancers. Clin Infect Dis. 2016;63(1):41-47

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Published

2024-03-11

How to Cite

KORSANTIA, N., KATSITADZE, A., TSISKARISHVILI, N., ADAMASHVILI, N., GOGINASHVILI, T., BIBICHADZE, M., … KATSITADZE, T. (2024). FAMILY HERPESVIRIDAE – AN OVERVIEW. Experimental and Clinical Medicine Georgia, (1), 21–34. https://doi.org/10.52340/jecm.2024.01.04

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