TOPICAL – IVERMECTIN VS METRONIDAZOLE EFFICACY IN TREATMENT OF TELEANGIECTATIC-ERYTHEMATOUS-PAPULAR ROSACEA
DOI:
https://doi.org/10.52340/jecm.2024.02.03Keywords:
Acne Rosacea, 1% Ivermectin cream, % metronidazole cream, Bacterial ResistanceAbstract
Acne rosacea It is a recurrent, progressive inflammatory disease. In the treatment of rosacea, great importance is attached to local therapy, which requires it to have a fast anti-inflammatory and anti-parasitic effect, improve erythema and dilated blood vessels without causing skin irritation and developing bacterial resistance. It will also reduce the risk of developing a pustular form of rosacea and, thus, the need for oral and local antibiotic therapy. In our study effective use and superiority of 1% ivermectin cream, which is in practice mainly used for papular-pustular subtypes of rosacea, compared to 1% metronidazole cream was established for early subclinical forms of rosacea.
Downloads
References
L.Gether, L.K.Overgaard, A.Egeberg, J.P.Thyssen. Incidence and prevalence of rosacea: a systematic review and meta-analysis. British Journal of Dermatology. 2018;179:282–9. doi 10.1111/bjd.16481
Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC. Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience. J Am Acad Dermatol. 2019;80(6):1722–9.e7. doi:10.1016/j.jaad.2018.08.049
Two AM, Wu W, Gallo RL, Hata TR. Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors. J Am Acad Dermatol. 2015 May. 72 (5):749-58; quiz 759-60.
ალექსანდრე კაციტაძე, დერმატოლოგია და ვენეროლოგია, 2020. თბილისი, საქართველო
Lallas A, Argenziano G, Apalla Z, Gourhant JY, Zaballos P, Di Lernia V, et al. Dermoscopic patterns of common facial inflammatory skin diseases. J Eur Acad Dermatol Venereol. 2014;28:609–14.
Tan J, Liu H, Leyden JJ, Leoni MJ. Reliability of clinician erythema assessment grading scale. J Am Acad Dermatol. 2014;71:760–3.
Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, et al. Standard classification of rosacea: report of the National Rosacea Society expert committee on the classification and staging of rosacea. J Am Acad Dermatol 2002;46:584-7.
Zuber TJ. Rosacea. Dermatology. 2000;27:309–18.
Soolantra (ivermectin) cream, 1% for topical use (prescribing information) fort worth, TX, GALDERMA LABORATORIES, LP; DECEMBER 2014.
Stein L, Kircik L, Fowler J, Tan J, Draelos Z, Fleischer A, Appell M, Steinhoff M, Lynde C, Liu H, Jacovella J. Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies. J Drugs Dermatol. 2014 Mar;13(3):316-23. PMID: 24595578.
Ci X, Li H, Yu Q, et al. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fundam Clin Pharmacol. 2009; 23:449–455.
Nato Korsantia, N.Kiladze, T.Katsitadze, L.Beridze, Nino Korsantia. Using of Dermoscopy in general dermatology (literature revue). Experimental and Clinical Medicine. Tbilisi, 2020,5,42-46