VITAMIN D STATUS AND ITS CORRELATION WITH SYSTEMIC CYTOKINE LEVELS IN PEDIATRIC PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA
DOI:
https://doi.org/10.52340/jecm.2022.03.04Ключевые слова:
children, pneumonia systemic cytokines, vit DАннотация
The aim of present study was to establish correlations between vit D status and systemic cytokines profile in children with community acquired pneumonia (CAP). The prospective study was performed in 41 Children with CAP at age 5 to 15 years hospitalized in TSSU Zhvania Pediatric Academic Clinic between November 2019 to March 2021 (negative SARS-2-CoV). Vit D One moment blood concentrations of 25-hydroxyvitamin D were determined in every study participant. According to recent consensus, a 25(OH)D concentration <50 nmol/L, or <20 ng/mL was an indication of vitamin D deficiency, a 25(OH)D concentration of 50–75 nmol/L, or 20–30 ng/mL was considered to indicate insufficiency; concentrations >75 nmol/L to 250 nmol/L, or 20 ng/mL-100ng/mL was considered to be sufficient. Interleukin (IL) 6 and 10 were determined twice on first and fifth days of hospital admission in the blood of each patient. I group (11 cases) formed patients with vit D deficiency, II group (12 cases) with vit D insufficiency and control group (18 cases) formed hospitalized patients with sufficient vit D concentration. Normal values in healthy population for IL-6 2.9±0.3 pg/ml, for IL-10 1.32±1.5pg/ml.Data were analyzed using computer program SPSS 18 (SPSS INC., CHICAGO, IL, USA). Statistical significance was taken as p<0.05. Serum levels of IL-6 and IL-10 upon admission were significantly higher in every patient to compare to normal data. IL-6 in vit D deficient patients were significantly increased, as at admission, as on 5-th day of hospitalization compared with other groups. On 5-7th hospital day IL-6 in vit D insufficient and sufficient patients had already normalized to levels similar to those of healthy individuals. Whereas IL 10 level stay high in four patients who required intensive care for ARDS. Our results have shown that the systemic cytokines levels and IL6/IL/10 ratio are increased in CAP patient. Vit D plasma concentration affects systemic cytokines levels in the blood. Vit D deficiency (<20ng/ml) can be recognized as risk-factor for pneumonia severity.
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Akhayeva A, Azizov I, Kenzhetayeva T, et al. Diagnostic value of IL-6 for community-acquired pneumonia in children. Archives of the Balkan Medical Union 2017, 52, 2, 152-155.
Bacci MR., Leme R C P ., Zing N P C . et al. IL-6 and TNF-α serum levels are associated with early death in community-acquired pneumonia patients. Braz J Med Biol Res. 2015 May;48(5):427-32. doi: 10.1590/1414-431X20144402. Epub 2015 Feb 24.
Bouillon R., Marcocci C., Carmeliet G. et al. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. ndocr Rev. 2019 Aug; 40(4): 1109–1151.
de Brito RC, Lucena-Silva N, Torres LC, Luna CF, Correia JB, da Silva GA. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulm Med. 2016; 16(1):170.
Garg D, Bhalla K, Nanda S, Gupta A, Mehra S. Vitamin D status in children with community acquired pneumonia and its association with severity: a hospital-based study. Minerva Pediatr (Torino). 2021 Apr 12. doi: 10.23736/S2724-5276.21.06036-9.
Grossman Z., Hadjipanayis A., Stiris T. et al. Vitamin D in European children-statement from the European Academy of Paediatrics (EAP). European Journal of Pediatrics, volume 176, pages 829–831 (2017)
Haugen J. Basnet S, Hardang IM, et al. Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia. Pediatr Res. 2017 Dec;82(6):986-993. doi: 10.1038/pr.2017.71. Epub 2017 Aug 16.
Holick MF., Binkley NC, Bischoff-Ferrari HA et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 7, 1 July 2011, Pages 1911–1930, https://doi.org/10.1210/jc.2011-0385
Jachvadze M., Gogberashvili K. Assessment of Knowledge Level Among Georgian Parents About Vitamin D Influence on Child’s Health. Questionnaire Survey. GMN, 2020; 10(307):158-161.
Jachvadze M., Shanidze L., Gubelidze N., Gogberashvili K. Vitamin D Status Among Georgian Children with High Acute Respiratory Morbidity. GMN, 2021;5(314):95-99.
Kearns MD., Alvarez JA., Seidel N., Tangpricha V. The impact of vitamin D on infectious disease: a systematic review of controlled trials. Am J Med Sci. 2015 Mar; 349(3): 245–262. doi: 10.1097/MAJ.0000000000000360
Kim H.O., Kim HS., Youn JCh., Shin E.Ch., Park S. Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays. J Transl Med. 2011; 9: 113.Jul 20. doi: 10.1186/1479-5876-9-113
Mailhot G., White JH. Vitamin D and Immunity in Infants and Children. Nutrients. 2020 May; 12(5): 1233.
Martineau AR., Jolliffe DA.,Greenberg L et al., Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health Technol Assess. 2019 Jan;23(2):1-44. doi: 10.3310/hta23020.
Paats M., S, Bergen I., M,, Hanselaar W. et.al. Local and systemic cytokine profiles in non -severe and severe community-acquired pneumonia. European Respiratory Journal, 2013 41: 1378-1385; DOI: 10.1183/09031936.00060112
Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? Journal of Steroid Biochemistry & Molecular Biology. 2014;144(2014):138-145.
Peñaloza H, Schultz BM, Nieto PA, et al. Opposing roles of IL-10 in acute bacterial infection. Cytokine Growth Factor Rev. 2016 Dec;32:17-30.
WHO. Pneumonia. Geneva: World Health Organization; 11 November, 2021 (http://www.who.int/mediacentre/factsheets/fs331/en/)
WHO. Vitamin D for prevention of respiratory tract infections. Geneva: World Health Organization; 2016. (http://www.who.int/topics/respiratory_tract_diseases/en/)
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