SARCOIDOSIS WITH PROLONGED REMISSION – A CLINICAL CASE REPORT
Keywords:Sarcoidosis, Prolonged remission, Clinical case
Sarcoidosis is a rare multisystem disease characterized by the development of inflammatory granulomatous formations in tissues without caseous necrosis. It can involve any organ or system where T-lymphocytes and mononuclear phagocytes are concentrated. Sarcoidosis usually occurs in adults of both sexes, although research shows that it is more common in females. Many infectious and non-infectious factors are considered as probable causes of the development of sarcoidosis. This article describes pulmonary sarcoidosis in a 41-year-old woman, whom we have been monitoring since 2015. The patient came to the clinic with complaints: shortness of breath, spasmodic cough, pain in the left ring area. She was initially treated with a diagnosis of pneumonia, without success. Radiography of the lungs showed lymphadenopathy of the roots and mediastinum of the lungs, along with changes in the lung parenchyma. In order to rule out oncological disease, additional studies were appointed: on chest computer tomography - enlarged tracheobronchial lymph nodes; by fibrobronchoscopy: tubular bronchiectasis; By cytology of the washed material: leukocytes and lymphocytes were seen in the mucus, by biopsy: non-caseous granulomatosis. As a result of examination, a diagnosis of pulmonary sarcoidosis was made. Treatment with hormonal drugs was prescribed. For the purpose of continuous monitoring, the patient has been under observation for 3 years and instrumental-laboratory studies are being conducted, steroid treatment is continued according to the appropriate scheme. At this stage, the disease is not progressing and is manageable, remission has been achieved. There are no additional complications.
Boiko DM, Pecherytsia VH, Boiko OS, Kulyk SM. [socioecological features of the epidemiology of sarcoidosis in the Poltava region, Ukraine]. Wiad Lek. 2018;71(3 pt 1):501-507. Ukrainian. PMID: 29783213.
Cooper D, Suau S. Sarcoidosis. Emerg Med Clin North Am. 2022 Feb;40(1):149-157. doi: 10.1016/j.emc.2021.08.012. Epub 2021 Oct 29. PMID: 34782085.
Hena KM. Sarcoidosis Epidemiology: Race Matters. Front Immunol. 2020 Sep 15; 11:537382. doi: 10.3389/fimmu.2020.537382. PMID: 33042137; PMCID: PMC7522309.
Kamangar N, Rohani P, Shorr AF (6 February 2014). Peters SP, Talavera F, Rice TD, Mosenifar Z (eds.). "Sarcoidosis". Medscape Reference. WebMD. Archived from the original on 10 February 2014.
Llanos O, Hamzeh N. Sarcoidosis. Med Clin North Am. 2019 May; 103(3):527-534. doi: 10.1016/j.mcna.2018.12.011. Epub 2019 Feb 21. PMID: 30955519.
Müller-Quernheim J, Prasse A, Zissel G (June 2012). "Pathogenesis of sarcoidosis". Presse Médicale. 41 (6 Pt 2): e275–87.
Nunes H, Bouvry D, Soler P, Valeyre D (November 2007). "Sarcoidosis". Orphanet Journal of Rare Diseases. 2: 46. doi:10.1186/1750-1172-2-46. PMC 2169207. PMID 18021432
Saidha S, Sotirchos ES, Eckstein C (March 2012). "Etiology of sarcoidosis: does infection play a role?". The Yale Journal of Biology and Medicine. 85 (1): 133–41. PMC 3313528. PMID 22461752
Syed J, Myers R (January 2004). "Sarcoid heart disease". The Canadian Journal of Cardiology. 20 (1): 89–93. PMID 14968147
van Maarsseveen, T. C. M. Th; Vos, W.; van Diest, P. J. (March 2009). "Giant cell formation in sarcoidosis: cell fusion or proliferation with non-division?". Clinical and Experimental Immunology. 155 (3): 476–486.
doi:10.1111/j.1365-2249.2008.03841.x. ISSN 1365-2249. PMC 2669524. PMID 19077083.