THE ROLE OF INFLAMMATION IN AGE-RELATED DISEASES
Keywords:age-related diseases, inflamation, inflamatory aging
The risk of developing of the diseases such as Alzheimer's disease, atherosclerosis, osteoporosis, arthritis, type 2 diabetes and cancer increases with age. This is why these diseases are also referred to as age-related diseases. There is evidence that the development of age-related diseases significantly contributes to the so-called. Immune aging, in particular, age-related changes in the immune system, one of the manifestations of which is a low level systemic chronic inflammation. The term "inflammatory aging" (Inflamm-aging) well describes the close relationship between low-grade chronic inflammation and aging. At the present stage of the development of medicine, the mechanisms associated with the development of age-related, low-level, chronic inflammatory processes and the ways of their evaluation require further in-depth, multidisciplinary studies. Clearly, inflammatory aging is a predictor of many age-related disease development and high risk of death. Clinical studies have confirmed the view that inhibition of certain mediators of inflammation may reduce the incidence of age-related diseases. However, similar studies focusing on anti-inflammatory drugs are few in number and the results are ambiguous. Further fundamental and translational studies in this direction hope that in the future we will be able to regulate inflammatory processes in a way that ensures a healthy and long-lasting aging of the population.
Bonaventura A, Liberale L, Carbone F, Scopinaro N, Camerini G, Papadia FS, Cordera R, Dallegri F, Adami GF, Montecucco F. High baseline C-reactive protein levels predict partial type 2 diabetes mellitus remission after biliopancreatic diversion. Nutr Metab Cardiovasc Dis 2017; 27:423–429.
Boren E, Gershwin M. E. Inflamm-aging: autoimmunety, and the immune-risk phenotype, Autoimmunity Reviews, 2004, vol. 3, no. 5:401–406.
Brandhorst S, Longo VD. Dietary restrictions and nutrition in the prevention
and treatment of cardiovascular disease. Circ Res 2019; 124:952–965.
Camici GG, Savarese G, Akhmedov A, Luscher TF. Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease. Eur Heart J 2015; 36:3392–3403.
Cannizzo ES, Clement CC, Sahu R, Follo C, Santambrogio L. Oxidative stress, inflamm-aging and immunosenescence. J Proteomics. 2011, Oct 19; 74(11):2313-23.
Carbone F, Adami G, Liberale L, Bonaventura A, Bertolotto M, Andraghetti G,
Scopinaro N, Camerini GB, Papadia FS, Cordera R, Dallegri F, Montecucco F.
Serum levels of osteopontin predict diabetes remission after bariatric surgery.
Diabetes Metab 2018;45:356–362.
Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, Curat CA, Sicard A,
Rome S, Benis A, Zucker JD, Vidal H, Laville M, Barsh GS, Basdevant A, Stich V,
Cancello R, Langin D. Weight loss regulates inflammation-related genes in white
adipose tissue of obese subjects. FASEB J 2004; 18:1657–1669.
De Martinis M., Franceschi C., Monti D., and Ginaldi L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity, FEBS Letters, 2005, vol.579, no.10:2035–2039.
Fagnoni F.F., Vescovini R., Passeri G., Bologna G., Pedrazzoni M., Lavagetto, G, Casti A., Franceschi C., Passeri M., Sansoni P., Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging. Blood, 95, (2000), 2860–2868.
Franceschi C, Garagnani P, Vitale G, Capri M, Salvioli S. Inflammaging and ‘Garb-aging’. Trends Endocrinol Metab 2017,28:199–212.
Franceschi C., Bonafe M., Valensin S. et al., Inflamm-aging. An evolutionary perspective on immunosenescence, Annals of the New York Academy of Sciences, 2000, vol. 908, 244–254.
Franceschi C., Valensin S.,et al., Neuroinflammation and the genetics of Alzheimer’s disease: the search for a proinflammatory phenotype, Aging Clinical and Experimental Research, 2001, vol.13, 3, 163–170.
Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Chronic inflammation in the etiology of disease across the life span. Nat Med, 2019, 25:1822–1832.
Giunta B., Fernandez F., Nikolic W. V. et al. Inflammaging as a prodrome to Alzheimer’s disease, Journal of Neuroinflammation, 2008, vol. 5, article 51.
Giunta S., Is inflammaging an auto[innate]immunity subclinical syndrome? Immunity and Ageing, 2006, vol. 3, article 12.
Higgins LJ, Rutledge JC. Inflammation associated with the postprandial lipolysis
of triglyceride-rich lipoproteins by lipoprotein lipase. Curr Atheroscler Rep 2009;
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020, 395:497–506.
Lencel P, Magne D. Inflammaging: the driving force in osteoporosis? Medical Hypotheses, 2011, vol. 76, no. 3, 317–321.
Liberale L, Bonaventura A, et al. Early reduction of matrix metalloproteinase-8 serum levels is
associated with leptin drop and predicts diabetes remission after bariatric surgery. Int J Cardiol 2017; 245:257–262.
Liberale L, Bonaventura A, Vecchie A, Casula M, Dallegri F, Montecucco F, Carbone F. The role of adipocytokines in coronary atherosclerosis. Curr Atheroscler Rep 2017; 19:10
Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK,
Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L.
Long-term moderate calorie restriction inhibits inflammation without impairing
cell-mediated immunity: a randomized controlled trial in non-obese humans.
Aging (Albany NY) 2016;8:1416–1431.
Miki C., Kusunoki M., Inoue Y. et al., Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation, Surgery Today, 2008, vol. 38, no. 10, 873–878.
Minamino T., T. Yoshida, K. Tateno et al. Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis, Circulation, 2003, vol. 108, no. 18, 2264–2269.
Mirzaei H, Suarez JA, Longo VD. Protein and amino acid restriction, aging and
disease: from yeast to humans. Trends Endocrinol Metab 2014; 25:558–566.
Nathan C. and Ding A., Nonresolving inflammation, Cell, 2010, vol. 140, no. 6, 871–882.
Olivieri F., M. R. Rippo, A. D. Procopio., F. Fazioli. Circulating inflamma-miRs in aging and age-related diseases, Frontiers in Genetics, 2013, vol. 4, article 121.
Olivieri F., M. R. Rippo, V. Monsurro et al. MicroRNAs linking inflamm-aging, cellular senescence and cancer, Ageing Research Reviews, 2013, vol. 12, no. 4, 1056–1068.
Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 2009; 6:399–409.
Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340:115–126.
Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY). 2012, Mar;4(3):166-175.
Sipos F., Leiszter K., Tulassay Z. Effect of ageing on colonic mucosal regeneration, World Journal of Gastroenterology, 2011, vol.17, no. 25, 2981–2986.
Sun Y, Coppé JP, Lam EWF. Cellular senescence: the sought or the unwanted? Trends Mol Med 2018, 24:871–885.
Van Oostrom AJ, Rabelink TJ, Verseyden C, Sijmonsma TP, Plokker HW, De Jaegere PP, Cabezas MC. Activation of leukocytes by postprandial lipemia in healthy volunteers. Atheroscl. 2004; 177:175–182.
Wang YI, Bettaieb A, Sun C, DeVerse JS, Radecke CE, Mathew S, Edwards CM,
Haj FG, Passerini AG, Simon SI. Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS One 2013; 8: e78322.