• NINO TORIA Department of Immunology, Tbilisi State Medical University, Department of Interventional Radiology; Tbilisi State Medical University, Tbilisi, Georgia
  • MALKHAZ MIZANDARI Department of Immunology, Tbilisi State Medical University, Department of Interventional Radiology; Tbilisi State Medical University, Tbilisi, Georgia
  • TINATIN CHIKOVANI Department of Immunology, Tbilisi State Medical University, Department of Interventional Radiology; Tbilisi State Medical University, Tbilisi, Georgia



Pancreatic cancer remains a leading cause of cancer-related mortality. Negligible success in testing various therapeutic approaches is explained by an advanced stage of the tumor at the diagnosis when clinical symptoms start to present. Immunosuppressive and dense stroma is mainly responsible for rapid growth and insidious spread of pancreatic cancer and also for resistance to various treatments. Reconsidering existing treatment protocols to establish personalized approaches to each patient’s case seems yet to be an only rational strategy. The radiofrequency ablation (RFA) technique as a minimally invasive loco-regional therapy has widespread popularity due to the possibility of tumor eradication together with positive immune-modulation effects in many cancers. However, this effect declines from time to time. To maintain the effect, we performed 3 repetitive RFAs in the patients with inoperable pancreatic cancer. According to our study RFA is a safe and feasible procedure. Repetitive RFA can be used in combination treatment and as a bridge between local and systemic cancer treatments. Booster application of RFA procedure might be a promising option to improve survival rates in patients with pancreatic cancer.


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