VITAMIN D STATUS AND ITS CORRELATION WITH COMMUNITY ACQUIRED PNEUMONIA SEVERITY IN CHILDREN

VITAMIN D STATUS AND ITS CORRELATION WITH COMMUNITY ACQUIRED PNEUMONIA SEVERITY IN CHILDREN

Authors

  • MIRANDA JACHVADZE
  • KETEVAN GOGBERASHVILI

DOI:

https://doi.org/10.52340/jecm.2022.730

Keywords:

children, pneumonia severity, vitamin D deficiency

Abstract

To elucidate the role of vitamin D status on the outcome of pneumonia, we estimated the associations between vitamin D status and pneumonia severity in children. Material and Methods. A hospital based cross-sectional study was conducted in two hospitals. 97 children with community acquired pneumonia (CAP) aged 5-17 years were included in 3 research groups divided according vitamin D status. Vitamin D3 deficiency was defined as a level of serum vitamin D<20ng/ml. The history of the child’s illness and the results from the physical examination and laboratory/instrumental data were recorded in a standardized form. Oxygen saturation (SpO2), weight, and height were measured. Indicators of the severity of pneumonia for analysis were presence or absence of danger signs, hypoxemia, prolonged hospitalization, and ICU admission, consolidation on chest X-ray, high inflammatory markers. Statistics. Data analysis was performed using SPSS 18.0 (SPSS Inc., Chicago, IL, USA). The nonparametric tests were used to compare groups (Kruskal–Wallis and Mann–Whitney). Statistical significance was taken as p<0.05. Results. Children with 25(OH)D <20ng/ml had an increased risk for treatment failure and a longer duration compared with patients with levels ≥ 30ng/ml (p<0.001). Hypoxemia and respiratory distress syndrome were more common in vitamin D3 deficient patients (p<0.05). The leukocytosis was in positive correlation with vitamin D3 deficiency, but CRP level was not associated with the vitamin D3 status. Pneumonia cases with 25(OH)D level 20-30ng/ml to compare with vitamin D3 level > 30ng/ml cases did not show any significant differences in severity. Conclusion. Vitamin D deficiency (level < 20ng/ml) was associated with severity of CAP in children. There is not yet achieved any consensus about this question and the data from ongoing clinical trials are needed for better elucidation of this matter.

Downloads

Download data is not yet available.

References

Autier P. Mullie P., Macacu A. et al. Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomized trials. Lancet Diabetes Endocrinol 2017; 5: 986-1004.

Carr R., Mahmood D., McEvoy A. Vitamin D and Vitamin D Deficiency: How Much Do Parents Know. Arch Dis Child. 2015;100(S3): A84

Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, de Henauw S, Moreno L, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. (2016) 103: 1033–44. doi: 10.3945/ajcn.115.120873

Castillio M.E., Costa L.M.E., Barrios J.M.V., et al. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. www.elsevier.com/locate/jsbmb

Craig F. Munns, Nick Shaw, Mairead Kiely, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. Consensus Statement. J Clin Endocrinol Metab. 2016 Feb; 101(2): 394–415.Published online 2016 Jan 8. doi: 10.1210/jc.2015-2175

Das RR, Singh M, Naik SS. Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia. Cochrane Database of Systematic Reviews. 2018(7). pmid:30024634

Dean Pr., Florin T.A., Factors Associated with Pneumonia Severity in Children: A Systematic Review. Journal of the Pediatric Infectious Diseases Society, Volume 7, Issue 4, December 2018, Pages 323–334, https://doi.org/10.1093/jpids/piy046.

Hashemian H, Heidarzadeh A. Role of Vitamin D [25(OH) D] Deficiency in Development of Pneumonia in Children, Arch Pediatr Infect Dis. 2017; 5(3): e57276. doi: 10.5812/pedinfect.57276

Haugen J, Chandyo RK, Ulak M, et al. 25-Hydroxy-Vitamin D Concentration Is Not Affected by Severe or Non-Severe Pneumonia, or Inflammation, in Young Children. Nutrients 2017:9:52.

Haugen J. Basnet S, Hardang IM, et al. Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia. Pediatr Res. 2017 Dec; 82(6): 986-993. doi: 10.1038/pr.2017.71. Epub 2017 Aug 16.

Jachvadze M., Gogberashvili K. Assessment of Knowledge Level Among Georgian Parents About Vitamin D Influence on Child’s Health. Questionnaire Survey. GMN, 2020; 10(307):158-161.

Jat KR. Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies. Trop Doct. 2017 Jan; 47(1): 77-84. Epub 2016 May 13.

Kim M., Pfotenhauer DO., Jay H, Shubrook DO. Vitamin D Deficiency, Its Role in Health and Disease and Current Supplementation Recommendations. The Journal of the American Osteopathic Association, May 2017, Vol. 117, 301-305.

Kondratyeva E.I., Zakharova I.N., Ilenkova N.A., et al. Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors. Front. Pediatr., 19 November 2020 | https://doi.org/10.3389/fped.2020.583206

Martineau AR., Jolliffe DA., Greenberg L., et al. Vitamin D supplementation to prevent acute respiratory tract infections: individual participant data meta – analysis. Health Technol. Assess. 2019 Jan; 23(2): 1-44.

Oktaria V, Danchin M, Triasih R, et al. The incidence of acute respiratory infection in Indonesian infants and association with vitamin D deficiency. PLoS One. 2021 Mar 23; 16(3): e0248722.

doi: 10.1371/journal.pone.0248722.

Oktaria V, Triasih R, Graham SM, et al. Vitamin D deficiency and severity of pneumonia in Indonesian children. PLoS One. 2021 Jul 9; 16(7): e0254488.

Quesada-Gomez J.M., Entrenas-Castillo M., Bouillon R. Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: revised Ms SBMB 2020_166, J. Steroid Biochem. Mol. Biol. 202 (2020), https://doi.org/10.1016/j.jsbmb.2020.105719.

Revised WHO classification and treatment of childhood pneumonia at health facilities. Evidence summaries. World Health Organization. Geneva. 2014. Google Scholar.

https://apps.who.int/iris/bitstream/handle/10665/137319/9789241507813_eng.pdf

Singh N, Kamble D, Mahantshetti NS. Effect of Vitamin D Supplementation in the Prevention of Recurrent Pneumonia in Under-Five Children. Indian J Pediatr. 2019;86(12):1105–11. pmid:31346969

Soliman AT, De Sanctis V, Elalaily R, Bedair S., Kassem I. Vitamin D deficiency in adolescents. Indian J Endocrinol Metab. 2014 Nov; 18(1): S9-S16

World Health Organization. Vitamin D supplementation and respiratory infections in children 2019 [updated 29 March 2019; cited 2020 21 may 2020].

Available from: https://www.who.int/elena/titles/vitamind_pneumonia_children/en/.

Yakoob MY., Salam RA, Khan FR., Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev 2016; 11: CD008824

Downloads

Published

2022-01-29

How to Cite

MIRANDA JACHVADZE, & KETEVAN GOGBERASHVILI. (2022). VITAMIN D STATUS AND ITS CORRELATION WITH COMMUNITY ACQUIRED PNEUMONIA SEVERITY IN CHILDREN. Experimental and Clinical Medicine Georgia, (1). https://doi.org/10.52340/jecm.2022.730

Issue

Section

Articles

Similar Articles

1 2 3 4 5 6 7 8 > >> 

You may also start an advanced similarity search for this article.

Loading...