CORRELATION OF INSULIN-LIKE GROWTH FACTOR, ITS BINDING PROTEIN AND METABOLIC PARAMETERS IN PATIENTS WITH COLORECTAL CANCER – RESULTS OF MULTIPLE REGRESSION ANALYSIS

ZVIAD MAGLAPHERIDZE; VERA KAPETIVADZE; TAMAR LAZASHVILI; IRINA KAPETIVADZE

doi:10.52340/jecm.2025.02.11

EMON77: Login The 4Science Agen Trusted Slot Gacor Online Resmi

EMON77

EMON77: Login The 4Science Agen Trusted Slot Gacor Online Resmi

INFORMASI SITUS

Penilaian Pengguna

999.789.333+

Sistem Pembayaran

4 Metode

Layanan Support

24/7

Platform

AMB-ENGINE

PENAWARAN SPESIAL

BONUS REFFERAL EXTRA UNLIMITED

Minimal Deposit Rp. 25.000

Minimal Withdraw Rp 50.000

DAFTAR

EMON77: Login The 4Science Agen Trusted Slot Gacor Online Resmi

EMON77 mengoperasikan layanan bandar slot Mahjong gacor 88 terkini berlisensi yang menjadi pilihan nomor satu pemain slot Mahjong di Indonesia, bukan hanya karena koleksi game yang paling lengkap tetapi karena komitmen platform dalam memastikan setiap versi game Mahjong yang tersedia adalah yang paling terkini dengan pembaruan fitur dan perbaikan bug yang sudah diimplementasikan oleh provider. Status berlisensi resmi yang dipegang EMON77 sebagai bandar slot Mahjong gacor 88 memberikan perlindungan nyata kepada member, karena di bawah lisensi ini terdapat kewajiban hukum yang mengikat platform untuk membayar setiap kemenangan member tanpa terkecuali dan mempertahankan standar operasional yang sudah ditetapkan oleh badan regulasi yang berwenang. Situs toto resmi yang terintegrasi dalam ekosistem EMON77 hadir sebagai pelengkap sempurna layanan slot Mahjong, memberikan opsi taruhan angka yang juga berlisensi dan transparan kepada member yang ingin memvariasikan pengalaman taruhan online mereka tanpa harus berpindah ke platform lain yang belum tentu memiliki standar keamanan yang sama. Jackpot langsung cair hari ini yang menjadi promise paling konkret EMON77 kepada membernya diwujudkan melalui sistem pembayaran otomatis yang diprogram untuk memproses setiap permintaan penarikan jackpot dalam waktu tidak lebih dari beberapa menit setelah verifikasi kemenangan selesai, tanpa antrian manual yang bisa memakan waktu berjam-jam di platform lain. Dengan identitas lengkap sebagai bandar slot Mahjong gacor 88 terkini berlisensi sekaligus situs toto resmi yang jackpot-nya langsung cair hari ini, EMON77 menawarkan proposisi nilai yang benar-benar komprehensif dan sulit ditandingi oleh platform manapun yang hanya fokus pada satu jenis layanan taruhan online tanpa integrasi yang mulus dan berkualitas seperti yang sudah dibangun EMON77 selama ini.

FAQ SEPUTARAN PEMAIN SITUS EMON77

Apa itu EMON77 sebagai bandar Slot Mahjong Gacor 88 terkini berlisensi?

EMON77 adalah bandar Slot Mahjong Gacor 88 terkini yang sudah berlisensi resmi dan menyediakan situs toto resmi dengan jackpot langsung cair hari ini.

Apakah situs toto resmi EMON77 jackpot langsung cair hari ini?

Situs toto resmi EMON77 memang jackpot langsung cair hari ini tanpa lama, proses cepat dan terpercaya.

Bagaimana sistem dan layanan di EMON77 bandar Slot Mahjong Gacor 88?

Sistem di EMON77 bandar Slot Mahjong Gacor 88 sangat terpercaya dengan layanan cepat yang mendukung pemain setiap hari.

Kenapa harus pilih EMON77 untuk main slot Mahjong gacor?

EMON77 pilihan terbaik karena bandar Slot Mahjong Gacor 88 berlisensi, jackpot cair cepat, dan situs toto resmi yang aman.

Apa keunggulan jackpot di situs toto resmi EMON77?

Keunggulan jackpot di situs toto resmi EMON77 adalah pencairan langsung hari ini, transparan, dan winrate yang menguntungkan pemain.

REVIEW TERATAS MEMBER EMON77

Khairul M. ★★★★★

EMON77 benar-benar bandar Slot Mahjong Gacor 88 terkini berlisensi terbaik. Situs toto resmi dengan jackpot langsung cair hari ini membuat saya betah bermain setiap hari. Sistem terpercaya dan layanan cepatnya sangat membantu pemain.

2026-02-10

Iwan A. ★★★★★

Saya sudah coba EMON77 sebagai bandar Slot Mahjong Gacor 88 terkini, situs toto resmi yang jackpotnya cair instan. Pelayanan ramah dan proses cepat, recommended untuk yang mau menang besar.

2026-02-08

Hanabi K. ★★★★☆

Baru gabung di EMON77 bandar Slot Mahjong Gacor 88 berlisensi, jackpot dari situs toto resmi langsung cair hari ini. Rasanya aman dan menguntungkan banget main di sini.

2026-02-05

Sasuke M. ★★★★★

EMON77 jadi pilihan utama saya untuk Slot Mahjong Gacor 88. Toto resmi, jackpot cair tanpa lama, sistem terpercaya, dan layanan super cepat setiap hari.

2026-02-03

Rikudo R. ★★★★★

Pengalaman mantap di EMON77 bandar Slot Mahjong Gacor 88 terkini. Situs toto resmi jackpot langsung cair, semuanya terasa fair dan player friendly.

2026-02-01

Sasori S. ★★★★☆

Awalnya iseng daftar lewat link alternatif, eh malah betah. Tampilan EMON77 profesional, navigasinya simpel, sekali klik langsung main!

2026-01-29

CORRELATION OF INSULIN-LIKE GROWTH FACTOR, ITS BINDING PROTEIN AND METABOLIC PARAMETERS IN PATIENTS WITH COLORECTAL CANCER – RESULTS OF MULTIPLE REGRESSION ANALYSIS

Authors

ZVIAD MAGLAPHERIDZE Tbilisi State Medical University
VERA KAPETIVADZE Tbilisi State Medical University
TAMAR LAZASHVILI Tbilisi State Medical University
IRINA KAPETIVADZE Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2025.02.11

Keywords:

Colorectal Cancer, IGF-1, IGF-BP3, Insulin Resistance, Metabolic Syndrome

Abstract

The aim of the study was to study the correlation between insulin-like growth factor (IGF), its binding protein (IGF-BP3) and metabolic parameters in patients with colorectal cancer (CRC) through multiple regression analysis.

Methods. 50 patients with CRC were examined. Before the inclusion of patients in the study, the patients confirmed their willingness to participate in the study on the informed consent protocol. Blood serum of patients with malignant tumors was taken 2-3 days before surgery and determined: fasting and postprandial glucose (glucose oxidation method), fasting insulin and C-peptide (radioimmunoassay), IGF-1 and IGF-BP3 (ECLIA-assay). Insulin resistance (IR) was determined by the Homeostasis Model Assessment (HOMA) determining the HOMA-IR index. Lipid parameters were determined in the same blood samples by biochemical method. Anthropometric parameters, body mass index (BMI), systolic and diastolic blood pressure were determined for each patient. The obtained results were statistically processed through the computer program SPSS23.0. The significant factors (dependent variables) with a joint influence on the outcome were studied using the multiple linear regression model. On stage 1, IGF-1 was selected as the outcome, and on stage II – IGF-BP3.

Results. The factors with a joint influence on the value of IGF-1 were: gender, complaints - flatulence/gas/bloating and diarrhea, BMI, waist circumference, HOMA-IR, systolic blood pressure. The factors with a joint influence on the value of IGF-BP3 were: gender, complaints - flatulence/gas/bloating, HOMA-S, HOMA-IR, creatinine.

Conclusion. We should consider the gender of the patient, MS features - IR, obesity, hypertension as factors having a joint influence on the concentrations of IGF and IGF-BP3 in the patients with CRC. On the other hand, insulin sensitivity and the level of IGF-BP are negatively correlated with the development of CRC. Therefore, it is crucial to control these modifiable risk factors, primarily through lifestyle changes, which will be a major step in the prevention of CRC.

Downloads

Download data is not yet available.

References

Arcidiacono B, Iiritano S, Nocera A, Possidente K, Nevolo MT, Ventura V, Foti D, Chiefari E, Brunetti A. Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms. Exp Diabetes Res. 2012;2012:789174.

Christopoulos PF, Msaouel P, Koutsilieris M The role of the insulin-like growth factor-1 system in breast cancer licensee BioMed Central 2015;14:43.

Esposito K, Chiodini P, Capuano A et al. Colorectal cancer association with metabolic syndrome and its components: A systematic review with meta-analysis. Endocrine. 2013;44:634–647.

Hu J, Liu X, Chi J et al. Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.Cancer Biomark.2018;21:883

Crawley DJ, Holmberg L et al. Serum glucose and risk of cancer: A meta-analysis. BMC Cancer. 2014;14:985.

Clemmons DR. Role of insulin-like growth factor in maintaining normal glucose homeostasis. Horm. Res. 2004;62:77–82. doi: 10.1159/000080763.

Isley WL, Underwood LE, Clemmons DR. Dietary components that regulate serum somatomedin-C concentrations in humans. J. Clin. Investig. 1983;71:175–182.

De Ita JR, Castilla-Cortázar I, Aguirre GA et al. Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: An experimental approach to metabolic syndrome. J. Transl. Med. 2015;13:326.

Sesti G, Sciacqua A, et al. Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance. Diabetes Care. 2005;28:120–125.

Aguirre GA, De Ita JR, de la Garza RG, Castilla-Cortazar I. Insulin-like growth factor-1 deficiency and metabolic syndrome. J. Transl. Med. 2016;14:3.

Esposito K. Chiodini P. Capuano A et al. Colorectal cancer association with metabolic syndrome and its components: A systematic review with meta-analysis. Endocrine. 2013;44:634–647.

Hu J. Liu X. et al. Expressions of IGF-1. ERK. GLUT4. IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC. Cancer Biomark. 2018;21:883

Crawley DJ, Holmberg L. et al. Serum glucose and risk of cancer: A meta-analysis. BMC Cancer. 2014;14:985.

Yamada K, Araki S, Tamura M et al. Relation of serum total cholesterol. serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ. Int. J. Epidemiol. 1998;27:794–798.

Schoen RE, Tangen CM, Kuller LH, et al. Increased blood glucose and insulin. body size. and incident colorectal cancer. J. Natl. Cancer Inst. 1999;91:1147–11454. doi: 10.1093/jnci/91.13.1147.

Chung Y.W, Han D.S, et al. Association of obesity. serum glucose and lipids with the risk of advanced colorectal adenoma and cancer: A case-control study in Korea. Dig. Liver Dis. 2006;38:668–672.

Limburg PJ, Stolzenberg-Solomon RZ, Vierkant RA et al. Insulin, Glucose, insulin resistance, and incident colorectal cancer in male smokers. Clin. Gastroenterol. Hepatol. 2006;4:1514–1521.

Gunter MJ, Hoover DR, Yu H et al. Insulin. insulin-like growth factor-I. endogenous estradiol. and risk of colorectal cancer in postmenopausal women. Cancer Res. 2008;68:329–337.

Kabat GC, Kim MY et al. A longitudinal study of serum insulin and glucose levels in relation to colorectal cancer risk among postmenopausal women. Br. J. Cancer. 2012;106:227–232.

Vulcan A, Manjer J, Ohlsson B. High blood glucose levels are associated with higher risk of colon cancer in men: A cohort study. BMC Cancer. 2017;17:842.

Xu J, Ye Y, Wu H et al. Association between markers of glucose metabolism and risk of colorectal cancer. BMJ Open. 2016;6:e011430.

Goya L, de la Puente A, Ramos S et al. Regulation of insulin-like growth factor-I and -II by glucose in primary cultures of fetal rat hepatocytes. J. Biol. Chem. 1999;274:24633–24640.

Goya L, de la Puente A, Ramos S et al. Regulation of IGF-I and -II by insulin in primary cultures of fetal rat hepatocytes. Endocrinology. 2001;142:5089–5096.

Devesa J, Almengló C, Devesa P. Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth? Clin. Med. Insights Endocrinol. Diabetes. 2016;9:47–71.

Dogansen SC, Yalin GY, Tanrikulu S, Yarman S. Impact of Glucose Metabolism Disorders on IGF-1 Levels in Patients with Acromegaly. Horm. Metab. Res. 2018;50:408–413.

Tsugawa Y, Handa H, Imai T. Arginine induces IGF-1 secretion from the endoplasmic reticulum. Biochem. Biophys. Res. Commun. 2019;514:1128–1132.

Kanbur-Oksüz N, Derman O, Kinik E. Correlation of sex steroids with IGF-1 and IGFBP-3 during different pubertal stages. Turk. J. Pediatr. 2004;46:315–321.

Jogie-Brahim S, Feldman D, Oh Y. Unraveling Insulin-Like Growth Factor Binding Protein-3 Actions in Human Disease. Endocrine Reviews 2009, 30(5):417-437.

Livingstone C. Insulin-like growth factor-I (IGF-I) and clinical nutrition. Clin. Sci. 2013;125:265–280.

Chaudhari A, Gupta R, Patel S, Velingkaar N, Kondratov R. Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation. Mol. Biol. Cell. 2017;28:834–842.

Yan J, Charles JF. Gut Microbiota and IGF-1. Calcif. Tissue Int. 2018;102:406–414.

Downloads

Published

2025-05-25

How to Cite

MAGLAPHERIDZE, Z., KAPETIVADZE, V., LAZASHVILI, T., & KAPETIVADZE, I. (2025). CORRELATION OF INSULIN-LIKE GROWTH FACTOR, ITS BINDING PROTEIN AND METABOLIC PARAMETERS IN PATIENTS WITH COLORECTAL CANCER – RESULTS OF MULTIPLE REGRESSION ANALYSIS . Experimental and Clinical Medicine Georgia, (2), 58–66. https://doi.org/10.52340/jecm.2025.02.11

Download Citation

Issue

No. 2 (2025)

Section

Articles

Dapatkan gratis hadiah

EMON77: Login The 4Science Agen Trusted Slot Gacor Online Resmi

EMON77

INFORMASI SITUS

PENAWARAN SPESIAL

Pilih Antara Anda

{{upgrade.title}}

{{offerFinance.title}}

{{galaxyForever.title}}

Pilih warna Anda

Pilih warna skin Anda

Jenis modern

Jenis bevel

Warna skin

{{tradeIn.title}}

Dealer stock quantity

{{assuredBuyBack.title}}

{{newAssuredBuyBack.title}}

Benefits of EMON77

{{warranty.title}}

{{warrantyVd.title}}

{{delivery.headline}}

{{tariffOption.headline}}

{{embedAddon.title}}

EMON77: Login The 4Science Agen Trusted Slot Gacor Online Resmi

FAQ SEPUTARAN PEMAIN SITUS EMON77

REVIEW TERATAS MEMBER EMON77

CORRELATION OF INSULIN-LIKE GROWTH FACTOR, ITS BINDING PROTEIN AND METABOLIC PARAMETERS IN PATIENTS WITH COLORECTAL CANCER – RESULTS OF MULTIPLE REGRESSION ANALYSIS

Authors

DOI:

Keywords:

Abstract

Downloads

References

Downloads

Published

How to Cite

Issue

Section

Most read articles by the same author(s)

Similar Articles

Language

all