BLOOD NO CONTENT AS A MARKER OF MALIGNANT THYROID TUMOUR PATHOLOGY

IVANE  JAVAKHISHVILI; KONSTANTINE  MARDALEISHVILI; DAVID  METREVELI; SOFO  TURABEKIDZE-ROBAKIDZE; GIORGI  BURJANADZE; TAMAR  SANIKIDZE

doi:10.52340/jecm.2022.06.019

BLOOD NO CONTENT AS A MARKER OF MALIGNANT THYROID TUMOUR PATHOLOGY

Authors

IVANE JAVAKHISHVILI
KONSTANTINE MARDALEISHVILI
DAVID METREVELI
SOFO TURABEKIDZE-ROBAKIDZE
GIORGI BURJANADZE
TAMAR SANIKIDZE

DOI:

https://doi.org/10.52340/jecm.2022.06.019

Keywords:

thyreotoxicosis, tumour, carcinoma, NO

Abstract

The identification of early diagnostic markers of tumour pathology of the thyroid gland plays an important role. Our study aimed to determine changes in NO metabolism in various benign and malignant thyroid pathologies. The content of NO in the blood serum of healthy individuals and patients (with thyrotoxicosis, benign thyroid tumour and thyroid cancer) was studied. In patients with thyrotoxicosis, the content of NO in the blood serum increases statistically significantly by 33%, and in benign tumour pathology - by 22% compared with control indicators; In patients with thyroid cancer, the content of NO in the blood serum did not statistically significantly different from the level of control parameters.The present study has the potential to present elevated levels of NO in the blood of patients, compared with controls, as a marker to rule out thyroid cancer. Further clinical studies are needed to obtain comprehensive results and elucidate the relationship between NO metabolism and thyroid pathologies.

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