Peculiarities of Changes in the Proliferative Activity and Inflammatory Index of the Osteochondral Component and Synovial Membrane of the Hip Joint during Coxarthrosis
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The aim of the study was a comparative analysis of inflammatory changes and proliferative activity in the osteochondral component and synovial membranes of the joint according to the OARSI classification in Grade 4, Grade 5 and Grade 6 groups. Each study group included 20 cases. The study material used for the study consisted of depersonalized paraffin blocks from the archive material of the TSMU Educational-Scientific and Diagnostic Laboratory for the years 2019-2025. The study used hematoxylin & eosin technology, AgNOR technology to assess proliferative activity, and immunohistochemical technology to assess inflammatory index (CD45) and proliferative activity (Ki67). As the analysis of the results showed, in osteoarthritis, the inflammatory index increases with the degree of damage and it is manifested in almost the same way in the bone-cartilage component and synovial membranes. The dynamics of proliferative activity is manifested in the same way both with AgNOR technology and with the use of the proliferative marker Ki67 and it increases in accordance with the degree of damage.
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