The rate of stem cell division decreases with age

stem cells differentiation ESC ASC apoptosis ontogenesis self recovery senescence aging

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Intracellular repair and protection mechanisms determine the lifespan of an individual cell. Somatic stem cells determine the lifespan of all tissues and thus play an important role in the aging process of the body. Stem cells possess extensive self-renewal properties, but there is considerable evidence of their decline and erosion over time. The reason why the rate of division of stem cells decreases after each division is not yet determined. Interestingly, stem cells during asymmetric division selectively accumulate, on the one hand, newer molecules and structures, and on the other hand, older centrioles.

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