TGF-β in patients with hematologic malignancies


Hematologic malignancies

How to Cite

Nanava, N., Metreveli, S., Giorgobiani, G., Chikovani, T., & Janikashvili, N. (2022). TGF-β in patients with hematologic malignancies. GEORGIAN SCIENTISTS, 4(5), 33–40.


TGF-β expression is often increased in diseases such as malignancy, inflammation and fibrotic pathology. TGF-β ligand is involved in many processes of lymphoid cell development. TGF-β exerts an inhibitory stimulus on the differentiation and proliferation of stem cell progenitors. The amount of TGF-β on stem cell progenitors can determine various biological effects. For instance, if high concentrations of TGF-β have an inhibitory effect on stem cell progenitors, at low doses it can become stimulatory, especially in that group of stem cell progenitors that have a high probability of developing into myeloid cells.The aim of the study was to determine the level of TGF-β in the peripheral blood of patients with hematologic malignancies and to see its correlation with blood biomarkers of systemic inflammation.


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