CLINICAL CASE OF OVERLAP SYNDROME OF AUTOIMMUNE DISEASES

TINATIN KUTUBIDZE; MANANA KOBAKHIDZE; IRINE KEKELIDZE; MARIAM GHUGHUNISHVILI

doi:10.52340/jecm.2023.01.15

CLINICAL CASE OF OVERLAP SYNDROME OF AUTOIMMUNE DISEASES

Authors

TINATIN KUTUBIDZE
MANANA KOBAKHIDZE
IRINE KEKELIDZE
MARIAM GHUGHUNISHVILI

DOI:

https://doi.org/10.52340/jecm.2023.01.15

Keywords:

Sjögren’s syndrome, Celiac disease, overlap syndrome

Abstract

We are presenting a rare case of overlap of Sjögren’s syndrome (SS) and Celiac disease (CD). It is necessary to evaluate and diagnose timely the possible presence of other autoimmune diseases in the presence of any autoimmune disease, because they have about a 25% risk of developing several of them at the same time, which is called overlap syndrome. It is very important to do screening, follow up and regular GI care of Sjögren’s syndrome patients to identify CD case and help them to avoid severe malnutrition, hyponatremia, anaemia and later intestinal malignancies.

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References

Moutsopoulos HM, Bombardieri S. Sjogren’s syndrome. Rheumatology in Europe 1995; 24: 44-45.

Fox RI, Chan EK, Kang HI. Laboratory evaluation of patients with Sjögren’s syndrome. Clin Biochem 1992; 25: 213-222.

P. Brito-Zeron, C. Baldini, H. Bootsma, S.J. Bowman, R. Jonsson, X. Mariette, K. Sivils, E. Theander, A. Tzioufas, M. Ramos-Casals, Sjogren syndrome, Nat Rev Dis Primers 2 (2016)

Sheikh SH, Shaw-Stiffel TA. The gastrointestinal manifestations of Sjögren’s syndrome. Am J Gastroenterol 1995; 90: 9-14.

Green PH. The many faces of celiac disease: clinical presentation of celiac disease in the adult population. Gastroenterology 2005; 128 (Suppl. 1): S74-S78.

Rashtak S, Marietta EV, Murray JA. Celiac sprue: a unique autoimmune disorder. Expert Rev Clin Immunol 2009; 5: 593- 604.

Pittman FE, Holub DA. Sjögren’s syndrome and adult celiac disease. Gastroenterology 1965; 48:869-76

Iltanen S, Collin P, Korpela M, Holm K, Partanen J, Polvi A, Maki M. Celiac disease and markers of celiac disease latency in patients with primary Sjögren’s syndrome. Am J Gastroent 1999; 94:1042-1046.

Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993; 105: 910-922.

Kang HI, Fei HM, Saito I, Sawada S, Chen SL, Yi D, Chan E, Peebles C, Bugawan TL, Erlich HA et al. Comparison of HLA class II genes in Caucasoid, Chinese and Japanese patients with primary Sjögren’s syndrome. J Immunol 1993; 150: 3615-3623.

Mohan MP, Ramesh TC. Multiple autoimmune syndromes. Indian J. Dermatol Venerol Leprol 2003; 69: 298-299

Peter Szondaray at al. coeliac disease in Sjogren’s syndrome – a study of 111 Hungarian patients. Reumatol Int (2004); 24: 278-282