DETERMINATION OF COMMONTHYME (THYMUS VULGARIS L.)ESSENTIAL OIL LIPOSOMALINHALATION POWDER COMPOSITIONAND DEVELOPMENT OFTECHNOLOGY

Аннотация

Common thyme essential oil is characterized by pro-nounced and broad-spectrum antibacterial action.The study aimed to determine the composition and de-velop technology of Common thyme (Thymus vulgaris L.)essential oil liposomal inhalation powderBased on biopharmaceutical and technological studies,a formulation of a liposomal solution containing Commonthyme (Thymus vulgaris L.) essential oils has been com-piled, and a preparation technology was developed.The injection method is considered to be the optimalmethod of preparation of a liposomal solution containingCommon thyme (Thymus vulgaris L.) essential oil. Electronmicroscopy research of the prepared particles revealed thatthe nanoparticle sizes ranged from 230 to 250 nm.Based on biopharmaceutical and technological studies,the following ingredients have been selected for the prepa-ration of inhalation powder from the liposomal solution con-taining essential oil of Common thyme (Thymus vulgarisL.): Beta-cyclodextrin: Hydroxypropyl methylcellulose (70:30)as a “matrix-carrier”, against cohesion – cholesterol and Leu-cine – to decrease hygroscopicity.Common thyme (Thymus vulgaris L.) essential oil lipo-somal inhalation powder prepared with the provided formu-lation has a high ability to evacuate from the capsules.A laser diffractometer has established that liposomal in-halation powder of Common thyme (Thymus vulgaris L.)consists of optimal size respirable fractions.The degree of distribution of liposomal inhalation pow-der of thyme (Thymus vulgaris L.) at different levels of thelung has been studied. Results of In vitro experiments haveshown that the provided inhalation powder is distributedover the entire area of the lung, which is especially impor-tant in the treatment of diseases caused by bacterial infec-tions of the respiratory system.The technology of thyme liposomal inhalation powderhas been developed and the technological scheme of thepreparation is provided.sunTqvis sistemakompozicia #3I (piris Rru da xaxa)5% II (traqea) 35% III (bronqebi) 30% IV B(bronqiolebi) 20% V (alveolebi) 10%