PHARMACO-TECHNOLOGICAL ASSESSMENT OF SAKHARE LAKE

Аннотация

As a result of research conducted with a plasma atomic emission spectrometer, the content of essential macro and microelements in the water of Sakhara Lake has been determined. The research object contains sodium, potassium, calcium, magnesium, silicon, selenium, etc. in large amounts. which are necessary for the regulation of the functional activity of the skin, cardiovascular and musculoskeletal systems. It is established that the mineral water of Sakhare Lake has a weak antibacterial effect, which is probably due to high osmotic pressure. Based on biopharmaceutical studies, the composition of the hydrogel containing Sakhare Lake water is provided, %: API (Sakhare Lake water) 5.0; Methocel K100 1.0; Glycerin 10.0; potassium sorbate 0.2; distilled water up to 100.0. Studying the rheological characteristics, it was determined that the hydrogel has thixotropic properties, which indicates an optimal soft consistency, good spread ability and extrusion properties (ability to get out of the tube). With quality indicators: homogeneity, aqueous extract pH, colloidal stability, thermostability and viscosity, provided hydrogel meets the general requirements of the State Pharmacopoeia for semi-solid dosage forms. The technology of hydrogel preparation was developed and a technological scheme is provided. A structured system with predominantly coagulation-type connections is obtained, which is characterized by optimal spread ability and distribution on the surface.