THE ROLE OF MONTELUKAST IN MANAGEMENT OF CHILDREN WITH COVID-19 INFECTION
Keywords:COVID-19, cough, montelukast, children
Management of coronavirus infection especially in children is a continuous process of constant updating. It is difficult find the date about effect of montelukast in children with Covid-19 infection. According of this, the aim of the present article was to review the role of montelukast that could be beneficial in management of children with covid-19 infection. 76 patients (2 to 18 years of age, 43 girls, 33 boys) with the symptoms of dry and lingering cough were involved in the study. According to treatment design, the patients were divided into treatment groups. One part of the group was prescribed only inhalers, one part ‒ leukotriene receptor antagonists, one part ‒ antihistamines and the last one ‒ all three antihistamines simultaneously, respectively. Follow-up showed that the clinical effect of dry cough was more pronounced in patients administering montelukast only or in combination in comparison with the children taking only local glucocorticosteroid and antihistamines, such as desloratadine or levocetirizine separately, on a selective basis. The obtained results indicate the efficacy of montelukast, as symptomatic agents, for the treatment of Covid-19 patients with a dry and lingering cough. Research monitoring has also confirmed the ancillary effect of montelukast in children with Covid-19 infection.
Zhang J.J., Dong X., Cao Y.Y., Yuan Y.D., Yang Y.B., Yan Y.Q. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020 PubMed PMID: 32077115. Epub 2020/02/23.
Bisgaard H., Flores-Nunez A., Goh A., Azimi P., Halkas A., Malice M.P. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children. Am J Respir Critical Care Med. 2008; 178(8):854–860. PubMed PMID: 18583576. Epub 2008/06/28. Eng.
Noor A., Najmi M.H., Bukhtiar S. Effect of Montelukast on bradykinin-induced contraction of isolated tracheal smooth muscle of guinea pig. Indian J Pharmacol. 2011;43(4):445–449. PubMed PMID: 21845003. PubMed Central PMCID: PMC3153711. Epub 2011/08/17. Eng.
Brodlie M., Gupta A., Rodriguez-Martinez C.E., Castro-Rodriguez J.A., Ducharme F.M., McKean M.C. Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children. Cochr Database Syst Rev. 2015 CD008202. PubMed PMID: 26482324. Pubmed Central PMCID: PMC6986470. Epub 2015/10/21.