IMMUNODEFICIENT STATES IN PRETERM AND TERM INFANTS WITH RECURRENT RESPIRATORY DISEASES

KETEVAN BARABADZE; LELA NISHNIANIDZE; NINO ADAMIA; MIRANDA SHERVASHIDZE; DAREJAN KHACHAPURIDZE; IA PANTSULAIA

doi:10.52340/jecm.2022.06.05.02

IMMUNODEFICIENT STATES IN PRETERM AND TERM INFANTS WITH RECURRENT RESPIRATORY DISEASES

Authors

KETEVAN BARABADZE
LELA NISHNIANIDZE
NINO ADAMIA
MIRANDA SHERVASHIDZE
DAREJAN KHACHAPURIDZE
IA PANTSULAIA

DOI:

https://doi.org/10.52340/jecm.2022.06.05.02

Keywords:

respiratory distress, Immunodeficiency, diagnostics, infant, preterm infant

Abstract

Severe respiratory diseases are common manifestations of immunodeficiencies.The goal of our study is to reveal immunodeficient states in preterm infants with frequent severe respiratory diseases to improve management plans, prevent recurrences and minimize further lung damage.A case-control study was performed for 8 months. 53 preterm infants who had ARDS and were exposed to mechanical ventilation in the neonatal period, 6 of which showed CT scan abnormalities (fibrotic infiltrates, mosaic attenuation, ground-glass opacity), were compared to 32 term infants from the control group. Both groups presented with frequent severe respiratory diseases. IgG and IgA were deficient in 18 (33.96%) patients of the study group and 1 (3.125%) patient from the control group. The Fisher exact test statistic P-value is 0.0009.IVIG was transfused in 8 of the 18 preterm infants. During the next 3 to 7 months recurrence of the respiratory conditions was not reported in 6 (75%) patients; 1 (12.5%) patient experienced mild upper respiratory symptoms once, 1 (12.5%) patient was readmitted with respiratory failure. During 3 to 7 months at least one readmission was reported in 10 of 18 preterm patients who were not transfused IVIG.The research may reveal a correlation between frequent respiratory diseases and immunodeficiencies as either the cause or the result of the conditions in preterm babies, thus allowing us to improve management techniques to decrease recurrences and reduce further lung damage and readmission rates in the patients.

Downloads

Download data is not yet available.

References

James Fernandez , MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Overview of Immunodeficiency Disorders, Apr 2021

Medically reviewed by Nancy Carteron, M.D., FACR — Written by Danielle Dresden — Updated on July 5, 2021

NORD gratefully acknowledges Charlotte Cunningham-Rundles, MD, PhD, Departments of Medicine, Pediatrics, The Prism Immunology Institute, The Icahn School of Medicine at Mount Sinai, for assistance in the preparation of this report., Common variable immune deficiency. (2020).

https://rarediseases.org/rare-diseases/common-variable-immune-deficiency/ 2021

Primary care for persons who inject drugs. Visconti, A. J., et al.. https://www.aafp.org/afp/2019/0115/p109.html (2019)

Diagnostic approach to primary immunodeficiency disorders. Madkaikar M, Mishra A, Ghosh K. Indian Pediatr (2013) 50:579–8610.1007/s13312-013-0171-4

The case for newborn screening for severe combined immunodeficiency and related disorders. Puck JM. Ann N Y Acad Sci (2011) 1246:108–1710.1111/j.1749-6632.2011.06346.

The four most common immunodeficiencies. Stiehm RE. Adv Exp Med Biol (2007) 601:15–2610.1007/978-0-387-72005-0_2

Hampson FA, Chandra A, Screaton NJ, Condliffe A, Kumararatne DS, Exley AR, et al. Respiratory disease in common variable immunodeficiency and other primary immunodeficiency disorders. Clin Radiol (2012) 67:587–9510.1016/j.crad.2011.10.028

Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Conley ME, Cunningham-Rundles C, et al. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol (2014) 5:162.10.3389/fimmu.2014.00162

Costa-Carvalho BR, Wandalsen GF, Pulici G, Aranda CS, Sole D. Pulmonary complications in patients with antibody deficiency. Allergol Immunopathol (Madr) (2011) 39:128–3210.1016/j.aller.2010.12.003

de Gracia J, Vendrell M, Alvarez A, Pallisa E, Rodrigo MJ, de la Rosa D, et al. Immunoglobulin therapy to control lung damage in patients with common variable immunodeficiency. Int Immunopharmacol (2004) 4:745–5310.1016/j.intimp.2004.02.011

Rich AL, Le Jeune IR, McDermott L, Kinnear WJ. Serial lung function tests in primary immune deficiency. Clin Exp Immunol (2007) 151:110–310.1111/j.1365-249.2007.03550.