DETERMINATION OF STOMACH SOLUBLE AND FOAMING RABEPRAZOLE AND METRONIDAZOLE TABLETS FORMULATION

REVAZ ZAZADZE; LASHA BAKURIDZE; DALI BERASHVILI; ALIOSHA BAKURIDZE

doi:10.52340/jecm.2022.06.09

DETERMINATION OF STOMACH SOLUBLE AND FOAMING RABEPRAZOLE AND METRONIDAZOLE TABLETS FORMULATION

Авторы

REVAZ ZAZADZE TSMU Department of Pharmaceutical Technology, TSMU Department of Pharmaceutical Botany
LASHA BAKURIDZE TSMU Department of Pharmaceutical Technology, TSMU Department of Pharmaceutical Botany
DALI BERASHVILI TSMU Department of Pharmaceutical Technology, TSMU Department of Pharmaceutical Botany
ALIOSHA BAKURIDZE TSMU Department of Pharmaceutical Technology, TSMU Department of Pharmaceutical Botany

DOI:

https://doi.org/10.52340/jecm.2022.06.09

Ключевые слова:

Helicobacter pylori, Rabeprazole, Metronidazole, Foaming tablets

Аннотация

Since the discovery of Helicobacter pylori, numerous studies have been performed on its effective eradication, both in vitro and in vivo. Proton pump inhibitors, antibiotics of different groups, their modified drug form, etc. were tested. However, studies confirm that using these remedies does not achieve the desired pharmacotherapeutic effect.Foams - are light systems, have a large touch surface, completely cover the mucous membrane and penetrate into it. Concentrated solutions are not taken at the place of foam formation, which does not cause irritation of the mucous membrane. Characterized with high bioavailability and rapid therapeutic effect.The aim of the study was to determine the targeted delivery of H. pylori's eradication "gold standard" ingredients - rabeprazole and metronidazole, gastric soluble and foaming tablets.Taking into account the physico-chemical and technological properties of the active pharmaceutical ingredients, excipients are selected, their quantitative ratios are established, and the composition of rabeprazole and metronidazole foaming and gastric-soluble tablets is determined.Rabeprazole stomach-soluble and foaming tablets were prepared by direct compression with the use of excipients, including the antacid sodium bicarbonate, and metronidazole with the classic wet granulation.

Скачивания

Данные скачивания пока недоступны.

Библиографические ссылки

Mhaskar RS, Ricardo I, Azliyati A, Laxminarayan R, Amol B, Santosh W, et al. Assessment of risk factors of Helicobacter pylori infection and peptic ulcer disease. J Glob Infect Dis. 2013;5:60–7.

Mentis A, Lehours P, Megraud F. Epidemiology and diagnosis of Helicobacter pylori infection. Helicobacter. (2015) 20(Suppl. 1):1–7.

Suzuki H, Nishizawa T, Hibi T. Helicobacter pylori eradicationtherapy. Future Microbiol 2010;5:639–48.

Streubel A, Siepmann J, Bodmeier R. Gastro retentive drug delivery systems. Expert Opin Drug Deliv 2006;3:217–33.

Anurag Verma, Juhi Dubey, Rahul Rama Hegde, Vaibhav Rastogi, J. K. Pandit//Helicobacter pylori: past, current and future treatment strategies with gastro retentive drug delivery systems/Journal of Drug Target. 2016.Dec;24(10):897-915.

Veerapandian Chandrasekar, John Swamy Gabriela, K. Kannan and A. Sangamithra. Effect of foaming agent concentration and drying temperature on physiochemical and antimicrobial properties of foam mat dried powder. Asian J. Dairy & Food Res., 34 (1) 2015: 39-43

ON PHARMACEUTICAL DEVELOP¬MENT OF ORALLY DISINTEGRATING TABLET OF DIAZEPAM Thesis submitted to the Faculty of Pharmacy, University of Coimbra in partial fulfillment of the requirements for the degree of Master of Science in Medicine Technologies July 2014.

Granulation techniques & its updated modules/ Esratun Jannat, Abdullah Al Arif, Md. Mehdi Hasan, Abdullah Bin Zarziz and Harun Ar Rashid// The Pharma Innovation Journal 2016; 5(10): 134-141.

Sang-Ho Lee and Joo-Eun Kim/ Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet // Pharmaceutics 2021, 13, 259. https://doi.org/10.3390/pharmaceutics13020259.