PECULIARITIES OF EXTRACELLULAR MATRIX AND ANGIOGENESIS IN RECURRENT UTERINE LEIOMYOMAS DURING THE REPRODUCTIVE PERIOD

Abstract

Uterine Leiomyoma is stimulated by steroid hormones and local growth factors under conditions of aberrant apoptosis, and the extracellular matrix and its components also play an important role in its development. However, angiogenesis and vascularization are considered as crucial factors that control tumor growth. In addition, Leiomyomas have abnormal blood vessels and are less vascular than the surrounding myometrium. Aim of the study: the significance of the extracellular matrix in the angiogenesis of recurrent uterine leiomyoma at the periphery and central area of the nodules. Subject of research: Histological changes of uterine leiomyomas (42 patients) were studied. Research objectives: to identify the degree of angiogenesis and fibrosis in the periphery and central part of recurrent (from 4cm to 8cm) leiomyomas. Methodology: Ultrasonography, Histological study (with hematoxylin and eosin, Masson`s trichome).

Conclusion: on the basis of ultrasonographic and histological research on the periphery and central part of recurrent leiomyomas, it was revealed: 1. Light fibrosis on the periphery of the nodes with the presence of medium and large-caliber arteries and weakly expressed peripheral vascularization, and active fibrosis in the central part with the presence of remodeled blood vessels and small-caliber arteries. 2. The high degree of fibrosis detected in the center of the nodules with increased number of remodeled blood vessels and small-caliber arteries gives us the reason to assume the activation of angiogenesis in the mentioned area. 3. In recurrent leiomyomas, the high potential of blood vessels for self-renewal, differentiation, regeneration and constant active variation within the nodules, as a hormone-dependent process in terms of the formation of new remodeling blood vessels, is an important factor in the development of recurrence.