THE IMPACT OF GENETIC THROMBOPHILIA ON OBSTETRIC COMPLICATIONS AMONG GEORGIAN POPULATION
Keywords:genetic thrombophilia, obstetric complications, Georgian population
During the research, 160 women were examined with the obstetrics complications. The following parameters were evaluated to determine genetic thrombophilia: Leiden and prothrombin mutation (heterozygous and homozygous); homozygous mutation of plasminogen activator inhibitor (PAI-1); deficiency protein C, protein S and antithrombin III. There were 82 (51.3%) patients (group I) who had thrombophilic disorders, 78 (48.7%), who made up group II, did not have any form of thrombophilic disorders. There was no statistically significant difference between women with a history of stillbirth and preeclampsia. Preterm birth was observed in 20 (24,4%) women in group I and in 7 (8,8%) women in group II. The difference is statistically significant, OR 3,27. The women with a history of thrombosis complications during pregnancy and postpartum period were 14 (17,1%) among group I, and 4 (5,1%) - group II. The difference is statistically significant, OR 3,8. According to our data, the women with a history of preterm birth and thrombosis complications during pregnancy and postpartum period should be screened for the diagnosis of genetic thrombophilia.
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