RETROSPECTIVE ANALYSIS OF OPERATIVE MATERIALS OF PATIENTS OF REPRODUCTIVE PERIOD WITH LEIOMYOMA
Keywords:Leiomyoma, uterus, reproductive period, operative material
Leiomyoma is a benign tumor of unknown etiology of the uterus. Leiomyoma is stimulated by an excess of steroids, disruption of apoptotic mechanisms, and local growth factors.We conducted a retrospective analysis of the operative material with leiomyoma of the reproductive period of women with the uterine body. The study revealed: a sharp increase in the incidence of intramural leiomyoma; Histological structural features are characteristic of proliferative, recurrent, and latent leiomyomas; Active products of the extracellular matrix, which is important not only in terms of leiomyoma growth, but it is likely to be among the factors that limit the free uncontrolled spread of tumor proliferate in the uterine body muscle and inhibit the assimilation process; Retrospective analysis of the material provides a basis for the search for molecular mechanisms of leiomyoma development. The results obtained will be important for the selection of drug treatment (in terms of inhibition of myocyte proliferative processes, expression of growth factors and activation of apoptosis).
EA Stewart., CL Cookson., RA Gandolfo., R Schulze-Rath. Epidemiology of uterine fibroids: a systematic review. BJOG 2017; 124 (10) 1501-1512.
Maroo N. Ohara J. Wang H. Matsuot. Maruo, n. Ohara, J.; Wang, H.; Sexual steroid regulation of Matsuo uterine leiomyoma growth and apoptosis. Update on Human Reproduction, Volume 10, Edition 3, May 2004, 207-220.
Ingman WV and Robertson SA (2002) Determination of growth factor beta transformation actions in reproduction. Biographies 24, 904–914.
Laughlin SK, Schroeder JC, Baird DD. New directions in the epidemiology of uterine fibroids. Seminars in Reproductive Medicine. 2010; 28 (3): 204–217.
Malik M, Norian J, McCarthy-Keith D, Britten J, Catherino WH. Why are Leiomyomas called Fibroids: The Central Role of the Cell Matrix in Symptomatic Women. Semin Reprod Med. 2010; 28: 169–179.
Mosselman S, Polman J and Dijkema R (1996) ERβ: Identification and characterization of a new human estrogen receptor. FEBS letters 392. 49–53.
Peddada SD, Laughlin SK, Miner K, et al. Increase in uterine leiomyoma in premenopausal black and white women. Proceedings of the National Academy of Sciences of the United States. 2008; 105 (50): 19887–19892.
Stewart EA, Nowak RA. New concepts in the treatment of uterine leiomyoma. Bath. mach.1998; 92: 624–7
Rein MS (2000) Advances in the Study of Uterine Leiomyoma: The Progesterone Hypothesis. Environmental Health Perspective 108 (Appendix 5), 791–793